preformulation studies

Question 1

when preformulation studies is done

Answer 1

after pharmacology studies

Question 2

what is organoleptic properties

Answer 2

colour
taste
odour

Question 3

how to identify the purity of api and excipients

Answer 3

1. melting point
   - capillary method
   - hot stage
   - differential scanning calorimetry
2. HPLC,TLC,GC
3. Comparison between API which is 100% pure

Question 4

what is preformulation studies?

Answer 4

preliminary studies before the actual dosage design to identify the characteristic and physicochemical properties and helpin approach of formulation

Question 5

what is biopharmaceutical classification system

Answer 5

4 class

class 1: ⬆️permeability,⬆️ solubility
class 2: ⬆️permeability,⬇️solubility
class 3: ⬇️permeability ⬆️solubility
class 4: ⬇️permeability ⬇️ solubility

Question 6

what is intrinsic solubility

Answer 6

solubility when the compound is completely unionised

Question 7

intrinsic dissolution rate

Answer 7

dissolution rate from a unit of surface area of the drug

Question 8

what is constant in intrinsic dissolution rate

Answer 8

1. surface area
2. stirring rate
3. temperature
4. ph
5. ionic strength of dissolution

Question 9

how to measure intrinsic rate dissolution

Answer 9

1. rotating disk method

2. nelson comstant surface method

Question 10

why we need intrinsic rate dissolution

Answer 10

to prdict the influence of SOLUBILITY on IN VIVO DRUG DISSOLUTION AND ABSORPTION

Question 11

what is common ion effect

Answer 11

effect when two substance produce same in are involved in chemical equilibrium

Question 12

what is the function of common ion effect?

Answer 12

reduce solubility of less soluble electrolyte