dosage design 2

Question 1

what are the dissolution process?

Answer 1

1. solvation
2. hydration
3. dissociation

Question 2

what is solvation?

Answer 2

interaction between solute particles and solvent particles. the solute particles is surrounded by the solvent particles and seperated from each other

Question 3

what is hydration

Answer 3

almost the same with solvation but the solvent is water

Question 4

what is dissociation?

Answer 4

interaction between solute and solvent. The solute particles are separted by each other and surrounded by solvent. However the solute particles are individual molecule such as glucose.

Question 5

how does dissolution occur?

Answer 5

1. diffusion to the surface
2. adsorption to the surface
3. reaction on the surface
4. desorption on the surface
5. diffusion of products from the surface

Question 6

what is dissolution rate

Answer 6

amount of drug that dissolve per unit time under standardised condition of liquid, temperature and solvent composition.

Question 7

factors affecting dissolution process?

Answer 7

1. nature of solute and solvent
2. temperature
3. presence of mixing
4. interfacial surface area
5. presence of inhibitor

Question 8

factor affecting drug dissolution

Answer 8

1 physicochemical properties of drug

2 dosage form

Question 9

physicochemical properties of drug

Answer 9

1.particle size
2. solubility
3. polymorphism & amorphophism
4. salt form of drug
5 hydrate solvates

Question 10

dosage form that affect dissolution

Answer 10

1. pharmaceutical excipients
2. manufacturing process
   - method of granulation
   - intensity of packing of capsule content

Question 11

what is dissolution

Answer 11

a process where drug molecules dissolve

process by which solute dissolve in solvent to form solution