factor influencing drug stability

Question 1

factor affect solid dosage form

Answer 1

1. temperature
2. light
3. oxygen
4. moisture
5. excipients

Question 2

why ph is factor is so important for liquid dosage form?

Answer 2

1.hydrolysis of drug occur
2. oxidation dependent on pH
3 photochemical degradation dependence on pH

Question 3

drug degrade by oxidation which is ph dependent

Answer 3

prednisolone-base catalysed

morphine-alkakine or neutral

Question 4

prednisolone

Answer 4

base catalysed

Question 5

morphine

Answer 5

akaline or neutral

Question 6

photo degradation

ciprofloxacin

Answer 6

slightly basic

Question 7

acidic ph

photochemical

Answer 7

midazolam

Question 8

measures to be taken with oxygen sensitive

Answer 8

1. antioxidant
2. prevent from heavy metal
3. store in nitrogen or carbon dioxide container

Question 9

drug in micellar form has different rate of degradation due to

Answer 9

depend on location of drug in micelle

surface-easily attacked
deep in core-protected

Question 10

factor affect semisolid dosage form

Answer 10

depend on base

Question 11

excipient effect

starch,povidone

Answer 11

increase water content in tablet

Question 12

stearate salt

Answer 12

hydroxide ion catalysed degradation

Question 13

excipient give colour reaction

Answer 13

lactose

Question 14

pocidone, alginate

Answer 14

photolysis of drug

Question 15

effect of temperature on solid

Answer 15

melting

change shape

lose bound water

Question 16

liquid dosage form

Answer 16

1.ph 
2 temperature
3.solvent
4.light
5 ionic strength
6.oxgen
7. surfactant