diuretics Flashcards
1
Q
what is the concept for diuretic
A
- increase urine output, decrease blood volume
2. sodium not reabsorb, water so not reabsorbed
2
Q
type of diuretics
A
- high efficacy-loop diuretic
- intermediate efficacy-thiazides
- low efficacy-potassium sparing
3
Q
- furosemide
- bumetanide
- torsemide
- ethacrynic acid
A
high efficacy loop diuretics
4
Q
chlorothiazide
chlorthalidone
hydrochlorothiazide
indapamide
A
thiazide-intermediate drug
5
Q
potassium sparing
A
- spironolactone
- amiloride
- triamterene
6
Q
acetazolamide
dorsolamide
A
carbonic anhydrase inhibitor
7
Q
mannitol
urea
A
osmotic diuretic
8
Q
chlorthalidone-thiazide
A
long duration ction
9
Q
indapamide-thiazide
A
treatment of hypertension + renal failure
10
Q
what are the characteristic of thiazide drug?
A
- all have similar efficacies but different potencies
- hyperosmolar urine-substitute to ADH receptor
- treatment of diabetic insipidus
11
Q
what are the MOA of thiazide drug
A
- need to go to lumen to do it action
- act at distal convoluted tubule
- inhibit sodium and chlorine co trasport-increase sodium and calcium in urine
- reduce calcium in vascular-cause vasodilation
12
Q
- mild moderate ht
- mild moerate heart failure
- nephrogenic diabetes insipidus
- idiopathic hypercalciuria
A
thiazide
13
Q
adverse effect of thiazide
A
1. hypokalemia 2 hypomagnesemia 3 hyperglycemia 4 hyperuricemia 5 postural hypertension 6 hyperlipidemia 7 hypersensitivity
14
Q
drug interaction of thiazide
A
nsaid
anticoagulant
insulin
15
Q
potassium sparing diuretic
A
- use with thiazide to compensate potassium loss
- classified base on moa
