PPT RNA VIRUSES LAST Flashcards
FILOVIRIDAE
Ebola Virus
Natural host of ebola virus
fruit bat (Pteropodidae family)
targets endothelial cells, phagocytes, hepatocytes
Ebola virus
- can progress to DIC, diffuse hemorrhage, shock
- high mortality rate (100%)
Ebola Virus
Diagnosis of ebola virus
ELISA, antigen test and RT-PCR
Flaviviridae
Dengue virus
Zika Virus
Yellow Fever Virus
West nile Virus
Dengue virus transmission
bite of female Aedes aegypti mosquito (A. albopictus)
Spectrum disease of dengue virus
Dengue fever (Breakbone fever) and Dengue hemorrhagic fever
Diagnosis of disease dengue virus
NS1 antigen, RT-PCR, Dengue IgM and IgG, and CBC (platelet count)
Confirmed dengue
Viral culture isolation
PCR
Zika virus transmission
Aedes mosquito bites, sexual and vertical transmission (possible)
Zika virus spectrum of disease
conjunctivitis, low-grade fever, muscle and joint pain, headache, and PHOTOPHOBIA .
Zika virus complications
microcephaly and Guillain- Barre syndrome
Yellow fever virus reservoir
Monkey or human
Mot yellow fever virus
bite of Aedes or Haemagogus mosquito
Spectrum of disease yellow fever virus
characterized by jaundice and fever
Prostration and shock occur, accompanied by upper gastrointestinal tract hemorrhage with hematemesis (“black vomit”)
Yellow fever virus (flaviviridae)
Diagnosis of yellow fever virus
Councilman bodies (liver biopsy)
Transmission of West Nile Virus
bites of Culex mosquito
Spectrum of disease west nile virus
Encephalitis