Enveloped DNA VIRUS Flashcards
Vesicle filled with virus particles and cell debris
Herpes Simplex Viruses (HSV)
Gingivostomatitis
Herpes labialis (lips)
Keratoconjunctivitis
Temporal lobe encephalitis
Herpetic whitlow (fingers)
Herpes gladiatorum (trunk)
HSV-1 (HHV-1)
Causes temporal lobe encephalitis
HSV-1 (HHV-1
Genital herpes
Neonatal herpes (TORCH)
Aseptic meningitis
HSV-2 (HHV-2)
Diagnosis for HSV
Tzanck smear (multinucleated giant cells)
is the most common cause of sporadic, fatal encephalitis in the US
HSV-1
principal target area of the virus of HSV
Temporal Lobe
Chicken Pox
Varicella-Zoster Virus (VZV) / HHV-3
- Infects the URT, then spreads via the blood to the skin
Varicella-Zoster Virus
HHV-3 Becomes latent in the dorsal root ganglia, which may reactivate as
zoster
Unilateral painful vesicular eruption with a dermatomal distribution (thoracic and lumbar)
HERPES ZOSTER / SHINGLES
Most common complication of HHV-3
Debilitating pain (postherpetic neuralgia)
Varicella-Zoster Virus is also known as
HHV-3 /chicken pox
Most common complication of herpes zoster/shingles
Debilitating pain (postherpetic neuralgia)
Reactivation of latent VZV residing within geniculate ganglion
RAMSAY-HUNT SYNDROME / HERPES ZOSTER OTICUS
Fetuses infected at 6-12 weeks’ AOG: maximal interruption with limb development (short and malformed limbs covered with cicatrix – skin lesion with zigzag scarring associated with atrophy of the affected limb)
Congenital Varicella
Fetuses infected at 16-20 weeks’ AOG: eye and brain involve
CONGENITAL VARICELLA
Ramsay-Hunt Syndrome: treatment
Treatment
Valacyclovir
Prednisone
USES OF ASPIRIN IN PEDIATRIC DISEASES:
- Kawasaki
- ARF
- JRA
Most common intrauterine viral infection
CONGENITAL CMV INFECTION
Most common infectious cause of congenital abnormalities
CONGENITAL CMV INFECTION
Monospot-negative and HETEROPHIL-NEGATIVE MONONUCLEOSIS
CMV
owl’s-eye nuclear inclusion
Cytomegalovirus
Kissing disease’
Infectious mononucleosis
Infects mainly lymphoid cells, primarily B-lymphocytes through CD21
Epstein-Barr Virus (EBV) / HHV-4
Differential white blood cells count will show elevated “atypical lymphocytes”
Downey Cells
Use of amoxicillin in mononucleosis can cause characteristic
maculopapular rash.
most common AIDS-related malignancy
Kaposi sarcoma
rose-colored macules appear on body after several days of high fever; can present with febrile seizures; usually affects infant
ROSEOLA / EXANTHEM SUBITUM / SIXTH DISEASE
SIXTH DISEASE
Roseola/ Exanthem subitum