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MYCOLOGY VIROLOGY > DNA VIRUS > Flashcards

DNA VIRUS Flashcards

1
Q

DNA VIRUSES

A

HHAPPPPYy
Hepadna
Herpes
Adeno
Pox
Parvo
Papilloma
Polyoma

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2
Q

All dna virus are double stranded ecept

A

PARVOVIRUS

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3
Q

All dna virus have linear sna except

A

Papillomavirus (circular, supercoiled)
Polyomavirus ( circular, spuercoiled)
Hepadnavirus (circular, incomplete)

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4
Q

All dna virus are icosahedral except

A

Poxvirus (complex)

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5
Q

All dna virus replicate in the nucleus except

A

POXVIRUS (cytoplasm;carries own DNA-dependent RNA polymerase)

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6
Q

Parvoviridae virus

A

Parvovirus b19

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7
Q

only known human parvovirus (one serotype)

A

Parvovirus B19

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8
Q

Parvoviridae transmission

A

Close contact, probably respiratory, transplacental, or from blood and blood products

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9
Q

Fifth disease

A

Erythema infectiosum (slapped cheek rash)

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10
Q

Erythemainfectiosumor fifth disease [“slapped cheek” rash], transient aplastic crisis, fetal infection (fetal death and “hydrops fetalis”), arthritis, : red cell aplasia, and chronic B19 infection.

A

Parvovirus B19

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11
Q

Treatment for parvovirus

A

IV immunoglobulin can be used with aplastic crisis

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12
Q

Diagnosis for parvovirus

A

SEROLOGY
PCR
HISTOLOGY

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13
Q

Lace like rash on extremities

A

Parvovirus b19

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14
Q

Adenoviridae virus

A

Human adenovirus

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15
Q

no envelope with approx. 50 human serotypes

A

Human Adenovirus

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16
Q

Human adenovirus site of latency

A

Replication in oropharynx

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17
Q

URT: Pharyngitis, conjunctivitis, coryza serotype

A

3,7,8,19,37

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18
Q

LRT : bronchitis, atypical pneumonia serotype

A

Serotype 14

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19
Q

GIT: acute gastroenteritis (infantile diarrhea) serotype

A

40,41

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20
Q

GUT: acute hemorrhagic cystitis serotype

A

Serotype 7,11,21

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21
Q

Human adenovirus (URT)

A

Pharyngitis
Conjunctivitis
Coryza

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22
Q

Human adenovirus (LRT)

A

Bronchitis
Atypical pneumonia

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23
Q

Human adenovirus (GIT)

A

acute gastroenteritis

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24
Q

Human adenovirus (GUT)

A

Acute hemorrhagic cystits

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25
Q

Diagnosis for adenovirus

A

Cell culture (HEp-2) [Cowdry type B intranuclear basophilic inclusion bodies]
EIA for gastroenteritis (40-41)
PCR

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26
Q

Human adenovirus prevention

A

Vaccine (adenovirus 4 and 7) for military recruits

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27
Q

papovaviruses

A

pa = papilloma
po = polyoma
va — vacuolating agent

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28
Q

small nonenveloped icosahedral viruses which replicate in the nucleus and may transform infected cells.

A

Papovaviruses

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29
Q

HPV types 1 to 100+ (as determined by genotype; types defined by DNA homology, tissue tropism, and association with oncogenesis)

A

Papillomavirus

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30
Q

SV40, JC virus, BK virus, KI, WU, Merkel cell polyomavirus (MCPyV)

A

Polyomavirus

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31
Q

Double-stranded circular DNA genome replicated and assembled in nucleus

A

Papovaviridae

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32
Q

Human Papilloma Virus targets

A

Epithelial tissue (Infect squamous cells and induce formation of cytoplasmic vacuole (koilocytes)

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33
Q

Human Papilloma Virus transmission

A

Direct contact, sexual contact for genital warts

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34
Q

Human Papilloma Virus Disease

A

Skin and Genital warts, benign head and neck tumors, anogenital
:warts

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35
Q

Human Papilloma Virus treatment

A

Surgical or chemical removal; podophyllin

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36
Q

What type of HPV are the skin and plantar warts, verruca vulgaris

A

HPV 1,2,4,7

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37
Q

What type of HPV Genital Warts

A

HPV 6 and 11

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38
Q

Genital warts in HPV also known as

A

Condyloma acuminata

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39
Q

Most common viral std

A

HPV 6 and 11

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40
Q

HPV involves Carcinoma of the cervix, vulva, penis, anus

A

HPV 16,18,31,33

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41
Q

Treatment for Genital Warts

A

Podophyllin

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42
Q

Treatment for Skin warts

A

Liquid nitrogen

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43
Q

Treatment for Plantar warts

A

Salicylic acid

44
Q

JC Polyoma Virus or

A

John Cunningham virus

45
Q

Second smallest DNA virus

A

PAPOVAVIRIDAE

46
Q

The smallest DNA virus; the only DNA virus that is single-stranded.

A

PARVOVIRIDAE

47
Q

Causes progressive multifocal leukoencephalopathy in patients with AIDS

A

JC Polyoma Virus

48
Q

Demyelinating disease that affects the oligodendrocytes characterized by deficits in speech, coordination, and memory

A

JC POLYOMA VIRUS

49
Q

JC: Junky Cerebrum

50
Q

causes hemorrhagic cystitis and nephropathy in patients with solid organ (kidney) and bone marrow transplants

A

BK Polyoma Virus

51
Q

Diagnosis for BK polyoma virus

A

BKV blood test or a urine test for decoy cells
Biopsy of the kidneys
PCR techniques

52
Q

Polyomavirus

A

BK AND JC VIRUS

53
Q

Site of latency Polyomaviruses

54
Q

JC DIAGNOSIS

A

PCR (CSF and urine) or EM (brain tissue);

55
Q

Have large, enveloped, icosahedral capsids
containing double-stranded DNA genomes.

A

Herpesviridae

56
Q

Encode many proteins that manipulate the host
cell and immune response.

A

Herpesviridae

57
Q

Encode enzymes (DNA polymerase) that promote viral DNA replication and are good targets for antiviral drugs.

A

Herpesviridae

58
Q

DNA replication and capsid assembly occurs in the nucleus.

A

Herpesviridae

59
Q

Herpesviridae Virus is released by

A

Exocytosis by cell lysis, and through cell-to-cell bridges.
• Can cause lytic, persistent, latent, and (for Epstein- Barr virus) immortalizing infections.

60
Q

HHV-3 targets

A

Mucoepithelial and T cells

61
Q

HHV 4

A

Epstein-Barr virus

62
Q

HHV 8

A

Kaposi sarcoma-related virus

63
Q

HHV 5

A

Cytomegalovirus

64
Q

HHV 6

A

Herpes lymphotropic virus

65
Q

Targets b cells and epithelial cells

A

Epstein-barr virus (HHV-4)

66
Q

Targets lymphocytes and other cells

A

HHV 8 Kaposi sarcoma p-related virus

67
Q

Targets monocytes, granulocytes, lymphocytes and epithelial cells

A

HHV 5 Cytomegalovirus

68
Q

Herpes Simplex Viruses (HSV) virus

A

Herpes simplex virus types 1 and 2 (HSV-1 and -2)

69
Q

Transmission HSV 1

A

Saliva and direct

70
Q

Transmission HSV 2

A

Sexual or transvaginal

71
Q

Site of latency of HSV

A

Sensory nerve ganglia (neuron)

72
Q

Site of latency of HSV 1

A

Trigeminal ganglia

73
Q

Site of latency of HSV 2

A

Lumbosacral ganglia

74
Q

HSV DIAGNOSIS

A

Tzanck smear (multinucleated giant cell), Cowdry type A,
Cell culture (HDF, others), EIA, FA stain, PCR (CSF herpes encephalitis)

75
Q

HSV DISEASE

A

Vesicle filled with virus particles and cell debris

76
Q

is the most common cause of sporadic, fatal encephalitis in the USA

77
Q

Varicella-Zoster virus (VZV) site of latency

A

Dorsal root ganglia

78
Q

Varicella-Zoster Virus (VZV) / HHV-3

A

Chicken pox
Shingles
Ramsay Syndrome
Congenital varicella

79
Q

Chicken pox

80
Q

Shingles

A

Herpes zoster

81
Q

Dewdrop on a rose petal appearance

A

Varicella / Chicken pox

82
Q

Deliberating pain (postherpetic neuralgia)

A

Herpes zostes

83
Q

Reactivation of latent VZV residing within geniculate ganglion

A

Ramsay-hunt syndrome

84
Q

A triad of ipsilateral facial paralysis, ear pain, and vesicles on the face, on the ear, or in the ear is the typical presentation.

A

Ramsay-hunt syndrome

85
Q

asymptomatic infections, congenital disease of newborn, systemic infection of immunocompromised host, and heterophile negative IM

A

Cytomegalovirus

86
Q

Cytomegalovirus site of latency

A

WBCs, endothelial cells, cells in a variety of organs

87
Q

Cell culture (HDF), shell vial culture, CMV antigenemia, FA stain, PCR, negative heterophil test, Giant cells with “owl’s-eye” nuclear inclusion

A

Cytomegalovirus

88
Q

Infectious mononucleosis (IM) [“Kissing disease”], progressive, lymphoreticular disease, oral hairy leukoplakia in HIV-infected patients

A

Epstein-Barr Virus

89
Q

Epstein-barr virus site of latency

A

B lymphocytes (C3d complement)

90
Q

Downey cells

A

Epstein-barr virus / HHV-4

91
Q

HHV 6 and 7

A

Roseola (roseola infantum/exanthem subitum/6th
Diseased:isease),fever,malaise,rash,leukopenia,andinterstitial pneumonitis in organ transplant patients

92
Q

HHV 6-7 site pf latency

A

T lymphocytes (CD4 cells)

93
Q

Human herpesvirus type 8 (HHV-8) site of latency

A

viral genome found in Kaposi’s sarcoma tumor cells, endothelial cells, and tumor- infiltarting leukocytes

94
Q

HHV-8 disease

A

Kaposi’s sarcoma

95
Q

Poxviridae virus

A

Smallpox (variola) and molluscum contagiosum

96
Q

largest and most complex of all viruses; brick- shaped virion with nonconforming symmetry referred to as complex; dsDNA

A

Poxviridae

97
Q

all diseases of the skin

A

Poxviridae

98
Q

generalized infection with pustular rash;

99
Q

manifest benign nodules of skin.

A

molluscum contagiosum

100
Q

Only disease that has been eradicated from the face of the earth

101
Q

Prodome of fever and malaise followed by centrifugal rash

102
Q

SMALL POX HP

A

Guarnieri bodies

103
Q

Intracytoplasmic eosinophilic inclusions

A

Guarnieri bodies (smallpox)
Henderson-Patterson bodies (Molluscum contagiosum)

104
Q

Flesh colored dome shaped papules with central umbilication

A

Molluscum contagiosum

105
Q

Molluscum contangiosum HP

A

Henderson-Patterson bodies

MYCOLOGY VIROLOGY (12 decks)

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