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Gwen > PPP > Flashcards

PPP Flashcards

1
Q

Where does PPP occur

A

Cytosol

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2
Q

Why is PPP called a shunt?

A

It has intermediates of glycolysis

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3
Q

What are the intermediates between PPP and glycolysis

A

Glucose 6 phosphate
Fructose 6 phosphate
Glyceraldehyde 3 phosphate

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4
Q

What are the two phases in PPP

A

Oxidative and non oxidative phases

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5
Q

NADP-malic converts malate to?

A

Pyruvate and carbon dioxide

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6
Q

What is the end product of the oxidative phases?

A

Ribulose -5phosphate

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7
Q

NADP-isocitrate converts?

A

Isocitrate to alpha ketoglutarate forming NADPH in the process

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8
Q

Two tissues that require PPP?

A

Adrenal glands
Liver
Tests,ovary
Adipose tissue, mammary glands

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9
Q

How many CO2 are formed in the oxidative phase?

A

1

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10
Q

How many NADPH are formed in PPP

A

2

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11
Q

What is the rate limiting step in Pentose phosphate pathway

A

Glucose 6 phosphate dehydrogenase

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12
Q

6 phosphogluconolatone is converted to what? And by what enzyme?

A

To 6 phosphogluconate
By 6 phosphogluconolactonase enzyme

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13
Q

What Enzyme converts ribulose 5P to
1. Ribose 5 phosphate
2. Xylulose 5P

A
  1. Ribulose 5 phosphate isomerase
  2. Ribulose 5 phosphate epimerase
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14
Q

What enzyme takes 2 carbons from xylulose 5P to ribose 5P?

A

Transketolase.

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15
Q

Function of transaldolase

A

Takes 3 carbon atoms from sedoheptulose 7P to glyceraldehyde 3P

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16
Q

Rapidly dividing cells require?

A

Ribose 5 phosphate

17
Q

Glutathione is made of three things. These are?

A

Glutamic acid, cysteine and glycine

18
Q

Function of glutathione?

A

Maintains reduced state of a cell

19
Q

What is the most common enzyme deficiency in the body

A

Glucose 6 phosphate dehydrogenase

20
Q

Glucose 6 phosphate dehydrogenase deficiency protects against? Why?

A

Malaria.
Oxidative environment.

21
Q

P53 regulates?

A

Cell division

22
Q

What is required for the oxidation and reduction of glucothione

A
23
Q

What is the regulatory enzyme for PPP?

A
24
Q

What induces the synthesis of G6PD?

A

Increased insulin/glucagon ratio

Gwen (8 decks)

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