PPP

Question 1

Why is the PPP important to glutathione?

Answer 1

NADPH reduces glutathione to protect cells from oxidative damage

Question 2

What happens to cells when they have NADPH but need R5P to make NTP?

Answer 2

Oxidative phase is shut off, GAP and F^P go directly to Ribose-5-phosphate

Question 3

What happens when cells need both NADPH and nucleotides?

Answer 3

PPP uses oxidative phase

Question 4

What is the difference between transaldolase and aldolase?

Answer 4

Transaldolase adds and aldol, Rxn catalyzed by lysine

Question 5

What is the carbon delta for transladolase and transketolase?

Answer 5

transaldolase: C=3, transketolase is C=2

Question 6

What is the first stage of PPP?

Answer 6

oxidative stage, it oxidizes 2 carbons in glucose-6-phosphate to a lactone, generates two NADPH. Last step is an oxidative decarboxylation makes another NADPH and a 5 carbon sugar
g6p->lactone via glucose 6 dehydrogenase
lactone-> 6PG

Question 7

Where does PPP occur?

Answer 7

anabolic tissues like liver and fat