glycogenesis

Question 1

What is step one to glucogenesis?

Answer 1

UDP activates G1P for polymerization by removing inorganic pyrophosphate

Question 2

what is step 2 of glycogenesis?

Answer 2

glycogen synthase makes linear glucose chains by adding to glycogenic

Question 3

What makes glycogenic auto catalytic?

Answer 3

tryosine glycosyl transferase

Question 4

What is step 3 of glycogenesis?

Answer 4

branching enzymes introduce a1,6 linkage
a 14 and a16 bond forming are coupled

Question 5

What does converting one G1P to one UDP-glucose cost?

Answer 5

One UTP

Question 6

How does the fasted state stimulate glycogen breakdown?

Answer 6

glucagon activates GPCR that stimulates adenylate cyclase to make second messenger cAMP. cAMP activates protein kinase A which creates phosphorylation cascade ending in signal for glycogen phosphorylase

Question 7

How does the fed state simulate glycogen synthesis?

Answer 7

insulin promotes glycogen synthase which dephosphorylates and activates via PP1 and increases allosteric activation by G6P

Question 8

What happens to phosphoglucomutase when G6P is high(fed)?

Answer 8

Glycogenesis

Question 9

What happens to phosphoglucomutase when G6P is low (starved)?

Answer 9

glycogenolysis

Question 10

What is van gierkes disease?

Answer 10

muscle lacks glucose 6 phosphatase so no glucose exportation into blood. Hypoglycemia, liver enlargement, glycogen accumulation