PP Clues - Immunology Flashcards
Cytokines that Macrophages stimulate
IL-1
Cytokines that Th cells stimulate
Everything but IL-1
Enlarged lymph nodes that are most likely malignant
Supraclavicular
Epitrochlear
Inguinal
CD8
Tk (killer) or Ts (suppressor) cells
Responds to MHC I (self)
Cells that express MHC I
All cells except RBCs and platelets
CD4
Th (helper) cells
Responds to MHC II (non-self)
Type of immunity Th-1 provide
Cell mediated
Type of immunity Th-2 provide
Humoral
B-cell deficient PTs die from?
Bacterial infections
Common Variable Hypogammaglobulinemia (CVID)
Kids with B-cells that don't differentiate to plasma Low Ab Tyrosine kinase deficiency Late onset Frameshift/missense mutation
Bruton’s Agammaglobulinemia
Young adult with defective tyrosine kinase
No Ab
X-linked
Job’s Syndrome
Stuck in IgE stage
Red headed females
Tyrosine kinase deficiency
Multiple Myeloma
Multiple osteolytic lesions
IgG
Kappa light chains
Rouleaux formation
Heavy Chain Disease
IgA
Multiple myeloma of the GI tract
Selective IgG2 Deficiency
Recurrent encapsulated infections
Selective IgA Deficiency
Transfusion anaphylaxis
Mucous membrane infections
Hairy Cell Leukemia
Fried egg
TRAP (+)
Ataxia Telangectasia
Low IgA
Neuro problems
Hyper IgM Syndrome
High IgM
All other Ab LOW
Kinds of problems seen in PTs with defects in Cell Mediated Immunity
Viral Fungal Mycobacteria Protazoa Parasite Neoplasm
T-cell deficient PTs die from?
Viral infection
DiGeorge Syndrome
No thymus/inferior parathyroids
Low Ca2+ (only immunodeficiency with low Ca2+)
Problem with 3rd/4th pharyngeal pouches
Deletion on CH22
Chronic Mucocutaneous Candidiasis
T-cell defect against Candida albicans
Chronic fatigue
SCID
No thymus Frayed long bones Baby dies by 18mo Adenosine deaminase deficiency T-cells more affected than B-cells Frameshift/nonsense mutation Increase bacterial and fungal infections
