PP Clues - Immunology

Question 1

Cytokines that Macrophages stimulate

Answer 1

IL-1

Question 2

Cytokines that Th cells stimulate

Answer 2

Everything but IL-1

Question 3

Enlarged lymph nodes that are most likely malignant

Answer 3

Supraclavicular
Epitrochlear
Inguinal

Question 4

CD8

Answer 4

Tk (killer) or Ts (suppressor) cells

Responds to MHC I (self)

Question 5

Cells that express MHC I

Answer 5

All cells except RBCs and platelets

Question 6

CD4

Answer 6

Th (helper) cells

Responds to MHC II (non-self)

Question 7

Type of immunity Th-1 provide

Answer 7

Cell mediated

Question 8

Type of immunity Th-2 provide

Answer 8

Humoral

Question 9

B-cell deficient PTs die from?

Answer 9

Bacterial infections

Question 10

Common Variable Hypogammaglobulinemia (CVID)

Answer 10

Kids with B-cells that don't differentiate to plasma
Low Ab
Tyrosine kinase deficiency 
Late onset
Frameshift/missense mutation

Question 11

Bruton’s Agammaglobulinemia

Answer 11

Young adult with defective tyrosine kinase
No Ab
X-linked

Question 12

Job’s Syndrome

Answer 12

Stuck in IgE stage
Red headed females
Tyrosine kinase deficiency

Question 13

Multiple Myeloma

Answer 13

Multiple osteolytic lesions
IgG
Kappa light chains
Rouleaux formation

Question 14

Heavy Chain Disease

Answer 14

IgA

Multiple myeloma of the GI tract

Question 15

Selective IgG2 Deficiency

Answer 15

Recurrent encapsulated infections

Question 16

Selective IgA Deficiency

Answer 16

Transfusion anaphylaxis

Mucous membrane infections

Question 17

Hairy Cell Leukemia

Answer 17

Fried egg

TRAP (+)

Question 18

Ataxia Telangectasia

Answer 18

Low IgA

Neuro problems

Question 19

Hyper IgM Syndrome

Answer 19

High IgM

All other Ab LOW

Question 20

Kinds of problems seen in PTs with defects in Cell Mediated Immunity

Answer 20

Viral
Fungal
Mycobacteria
Protazoa
Parasite
Neoplasm

Question 21

T-cell deficient PTs die from?

Answer 21

Viral infection

Question 22

DiGeorge Syndrome

Answer 22

No thymus/inferior parathyroids
Low Ca2+ (only immunodeficiency with low Ca2+)
Problem with 3rd/4th pharyngeal pouches
Deletion on CH22

Question 23

Chronic Mucocutaneous Candidiasis

Answer 23

T-cell defect against Candida albicans

Chronic fatigue

Question 24

SCID

Answer 24

No thymus
Frayed long bones
Baby dies by 18mo
Adenosine deaminase deficiency 
T-cells more affected than B-cells
Frameshift/nonsense mutation 
Increase bacterial and fungal infections

Question 25

Wiskott-Aldrich

Answer 25

Low IgM
Low platelets
High IgA
Increased IL-4
Eczema 
Petechiae

Question 26

CD4 count tells you…

Answer 26

Status of HIV

Normal 800-1200, kids up to 1500