postnatal psych Flashcards

1
Q

how many blood vessels does the umbilical cord contain

A

1 vein - carries oxygenated blood to baby

2 arteries - carries deoxygenated blood back to placenta

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2
Q

3 shunts in fetal circulation

A

ductus venous
foramen ovale
ductus arteriosus

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3
Q

first breath of baby

A

Stimulated by: thorax is squeezed, temp change, sound, physical touch
- Strong first breath is required to expand the previously collapsed alveoli for the first time

Adrenalin + cortisol are released in response to stress of labour, stimulating respiratory effort

First breath expands alveoli, decreasing pulmonary vascular resistance
o This causes a fall in pressure in right atrium
o Left atrial pressure > right -> closes atrial septum, foramen ovale -> fossa ovalis

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4
Q

ductus arteriosus

A

Prostaglandins are required to keep the ductus arteriosus open
- Increased blood oxygenation causes a drop in circulating prostaglandins
o Causes closure of ductus arteriosus -> ligamentum arteriosum

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5
Q

ductus venosus

A

Stops functioning because umbilical cord is clamped + there is no blood flow in umbilical veins

It structurally closes a few days later + becomes ligamentum venosum

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6
Q

thermoregulation in utero

A

Lots of brown fat laid down between scapulae + around internal organs in 3rd trimester
o Less in growth restricted or preterm infants

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7
Q

thermoregulation of babys after delivery

A

Main source of heat production is non-shivering thermogenesis
o Heat produced by breakdown of stored brown adipose tissue in response to catecholamine

Not efficient in the first 12 hrs of life
- Peripheral vasoconstriction
- No shivering
- New-born babies need help!

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8
Q

glucose haemostasis in utero vs after delivery

A

In utero
- Glucose comes via placenta
- Glycogen stores created in liver + muscle in preparation for birth

After delivery
- Interruption of glucose supply from placenta
- Very little oral intake of milk
- Drop in insulin, increase in glucagon
- Mobilisation of hepatic glycogen stores for gluconeogenesis
- Ability to use ketones + lactate as brain fuel

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9
Q

transient tachypnoea + management

A

Babies born by elective C-section when mum has not been in labour + all the hormonal cues to stop lung fluid production in the baby have not happened
o Delay in baby reabsorbing all lung fluid + this makes breathing hard work for the first 12 hrs or so

Management
- Sometimes baby needs o2 or some pressure support
- Generally gets better quite quickly

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10
Q

red flag presentations in postnatal psychiatry

A
  • recent significant change in mental state
  • new thoughts or acts of violent self-harm
  • new _ persistent expression of incompetentcy as a mother or estrangement from their baby

(^ urgent referral to specialist mental health team)

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11
Q

when should admission to mother + baby unit be considered?

A
  • Rapidly changing mental state
  • Suicidal ideation – particularly of violent nature
  • Significant estrangement from the infant
  • Pervasive guilt or hopelessness
  • Beliefs of inadequacy as a mother
  • Evidence of psychosis

–> ie lower threshold for admission than general adult service

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12
Q

screening for mental health issues in pregnancy

A

booking appt - previous tx, FH, identify risk factors (young, single, domestic issues, substance misuse, unplanned)

screening (at every appointment)
o During the last month have you been bothered by feeling down, depressed or hopeless?
o During the last month have you been bothered by having little interest or pleasure in doing things?
o Is this something you feel you need or want help with?

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13
Q

baby blues

A

50% of women
brief period of emotional instability
tearful, irritable, anxiety + poor sleep confusion

day 3-10, self-liming

Mx = support, reassure

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14
Q

puerperal psychosis

A

presents within 2weeks of delivery
an emergency
mania, delusions, irrational ideas, confusion

**exclude sepsis
5% suicide risk, 4% infanticide

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15
Q

risk factors for pueral psychosis

A

bipolar disorder
previous puerperal psychosis
1st degree relative with history of bipolar behaviour

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16
Q

management of puerperal psychosis

A

admit to specialised mother-baby unit

80% 10yr recurrence
25% go onto develop bipolar disorder

17
Q

postnatal depression

A

onset 2-6wks
10% of women, 1/3 lasts a year or linger

effects on bonding, child development, marriage, risk suicide
screened for routinely

25% recurrence, 70% lifetime risk of depression

18
Q

untreated depression risk to child

A

low birth weight
pre-term delivery
adverse childhood outcomes - emotional+ conduct problems, ADHD
poor engagement/bonding with child - reduced infant learning + cognitive development

19
Q

postnatal depression management

A

mild-moderate - selfhelp, counselling

moderate-severe - psychotherapy + antidepressants
- sertraline or paroxetine -> all secreted in milk but ok
(avoid fluoxetine due to long half life)

20
Q

general antidepressant recommendations in pregnancy

A

women at high risk of relapse should be maintained on medication during + after pregnancy
- mod-severe - treat with antidepressanes

make use of priority access to psychological therapies during perinatal period

21
Q

antidepressants

A

use is increasingly common
SSRIs 1st line
- decision made of balance of risk

22
Q

SSRIs in preganncy

A

sertraline - least placental exposure
fluoxetine - thought to be safest

paroxetine - increased congenital malformations, less safe

23
Q

risks of SSRIs in pregnancy

A

1st tri - small increased risk of genital heart defects
3rd tri - persistent hypertension of newborn

lower birth weight
increased early birth - by matter of days
PPH

Risk of GI bleed - esp with NSAID

24
Q

SSRI drug interactions

A
  • NSAIDs, give PPI
  • Warfarin/heparin
  • Aspirin
  • Triptans – increased risk of serotonin syndrome
  • Monoamine oxidase inhibitors (MAOIs) – increased risk of serotonin syndrome
25
Q

venlafaxine + pregnancy

A

less evidence
cardiac defects + cleft palate, neonatal withdrawal

26
Q

antipsychotics + pregnancy

A

appear to be safe + no evidence of major teratogenicity

olanzapine + quetiapine have best evidence base

risks
- destational diabetes - esp 2nd gen
- reduced fertility due to raised prolaction levels

27
Q

bipolar affective disorder + pregnancy

A

high risk of relapse after delivery if mood stabilising mediactions are discontinued, esp in 1st month post partum

there is NO safe mood stabiliser

risks
- induction or csection
- preterm delivery
- small babies
- no increase in malformations

28
Q

mood stabilisers + pregnancy

A

NO safe one

valporation + carbamazepine -> most teratogenic
lamotrigine less bad than other anticonvulsants

aim to switch to safer antipsychotic - quetiapine or maybe lamotrigine

litium - ebsteins anomaly
- consider slow reduction preconception
- can be reintroduced in 2nd + 3rd trimester
- reintroduce immediately post partum

29
Q

anxiety + pregnancy

A

1st line = SSRIs
Benzodiazepines
o Not major teratogens
o 3rd trimester risk of “floppy baby”
o Generally thought to be problematic + be avoided

Zopiclone – risk

->Make use of priority access to psychological therapies during perinatal period

30
Q

when is best time to take psychotropic medication when breastfeeding

A

give doses before longest breaks between feeds

(should be taking lowest possible dose, avoid combos of meds)

31
Q

summary of psychotropic drugs in pregnancy

A

antidepressants
- sertraline 1st line
- no need to change from drug used in pregnancy

antipsychotics
- olanzapine, quetiapine
- avoid clozapine - agranulocytosis in infant

mood stbailisers
- antipsychotics
- avoid lithium - secreted in milk

32
Q

complications of substance abuse in pregnancy

A
  • Nutritional deficiency
  • HIV, hep C, hep B
  • VTE
  • STIs
  • Endocarditis/sepsis
  • Pour venous access
  • Opiate tolerance/withdrawal
  • IUGR, stillbirth, SIDs, pre-term labour

miscarriage
foetal alcohol syndrome - facial deformities, lower IQ, neurodevelopmental delay, epilepsy
wenickes/korsakoff

33
Q

risk of opiate use in pregnancy

A

neontal withdrawal
IUGR
SIDs
stillbirth

34
Q

risk of nicotine use in pregnancy

A

misscarriages
abruption
IUGR
stillbirth + sids

35
Q

cocaine, amphetamine, ectasy use in pregnancy

A

death via stroke + arrhythmias

teratogenic - microcephaly, limb defects
pre-eclampsia
abruption

IUGR, preterm labour
miscarriage
developmental delay
SIDs, withdrawal