Post Traumatic Stress Disorder Flashcards

1
Q

If intrusion symptoms, avoidance of reminders of a traumatic event, negative alterations in cognition and mood, and marked alterations in arousal and reactivity persist for less than 1 month, the condition is known as ______________.

A

Acute stress disorder

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2
Q

If intrusion symptoms, avoidance of reminders of a traumatic event, negative alterations in cognition and mood, and marked alterations in arousal and reactivity persist for more than 1 month, the condition is known as ______________.

A

Posttraumatic stress disorder

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3
Q

____________ results from exposure to actual or threatened death, serious injury, or sexual violence.

A

Trauma

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4
Q

____________ is the inability of an individual to prevent memories of a traumatic event from returning and becoming integrated into their daily life. This may manifest in distressing memories, recurrent stressful dreams, flashbacks, etc.

A

Intrusion

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5
Q

____________ is persistent evading and bypassing of stimuli associated with a traumatic event. This may manifest in avoiding people, places, conversations, activities, or subjects that have to do with said event.

A

Avoidance

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6
Q

___________ is the marked increase in arousal and reactivity associated with a traumatic event. This may be manifested in the form of reckless behavior, exaggerated startle response, sleep disturbances, hypervigilance, etc.

A

Hyperreactivity

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7
Q

_______________ and ____________ are common comorbidities associated with PTSD.

A

Depression and alcoholism

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8
Q

______________ occurs when a conditioned stimulus occurs repeatedly without its associated unconditioned stimulus, leading to loss of the conditioned response.

A

Extinction

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9
Q

__________ therapy works to bring about extinction of conditioned responses.

A

Exposure

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10
Q

PTSD is often associated with dysfunction of the _______________ cortex and ______________ of the limbic system.

A
  • Medial prefrontal cortex
  • Amygdala
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11
Q

The ____________ is the instinctual fear center of the brain. It is responsible for the acquisition and expression of fear conditioning.

A

Amygdala

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12
Q

Studies show (increased/decreased) amygdala activity in PTSD.

A

Increased

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13
Q

The ________________ provides the top-down, prefrontal control over the amygdala.

A

Medial prefrontal cortex (mPFC)

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14
Q

A (hyperactive/hypoactive) mPFC leads to higher autonomic arousal and exaggerated responses due to loss of inhibition of the amygdala.

A

Hypoactive

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15
Q

The amygdala projects to the __________ and __________ in order to elicit autonomic and behavioral reactions to fear.

A

Locus ceruleus and hypothalamus

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16
Q

_____________ is the neurotransmitter implicated in the startle response and fear reaction.

A

Norepinephrine

17
Q

The _____________ of the limbic system is involved in inhibiting stressful stimuli to end the fear response.

A

Hippocampus

18
Q

A (large/small) hippocampus is considered a risk factor of PTSD development.

A

Small hippocampus

19
Q

The coordinated response to stress is the release of __________ from the adrenal gland.

A

Cortisol

20
Q

Chronic PTSD is associated with (increased/decreased) levels of norepinephrine and (hyporeactivity/hyperreactivity) of α2 adrenergic receptors.

A
  • Increased levels of norepinephrine
  • Hyperreactivity of α2 receptors
21
Q

(T/F) Low cortisol release by the body in response to stressful stimuli has little to no effect on adrenergic activation.

A

False. Low cortisol allows for persistent adrenergic activation by norepinephrine.

22
Q

What are the treatments recommended for PTSD?

A
  • Psychotherapy
    • CBT
      • Prolonged Exposure Therapy (Gold Standard)
      • Cognitive Processing Therapy (CPT)
      • Eye Movement Desensitization Reprocessing
  • Pharmacotherapy
    • SSRIs (sertraline and paroxetine FDA approved)
    • Venlafaxine
    • Prazosin (α1 antagonist) - For sleep and nightmares mainly
23
Q

Benzodiazepines (are/are not) effective in the course of treatment for PTSD.

A

Are not