Portal hypertension

Question 1

Portal hypertension is defined as elevation of portal pressure

Answer 1

> 10-12mmHg

Question 2

Normal portal venous pressure

Answer 2

~7mmHg

Question 3

Portal htn can result from obstruction to portal blood flow anywhere along the course of

Answer 3

Portal venous system

Question 4

T/F Portal vein thrombosis is associated with hypercoagulable states such as deficiencies of factor V Leiden, protein C, or protein S

Answer 4

T

Question 5

Predominant cause of portal htn and is related to obstruction of blood flow through the portal vein

Answer 5

Cirrhosis

Question 6

Occurs with obstruction to hepatic veins anywhere between the efferent hepatic veins and entry of the IVC into the right atrium

Answer 6

Budd-Chiari Syndrome

Question 7

MCC of hepatic vein obstruction in children

Answer 7

Sinusoidal obstruction syndrome (veno-occlusive disease)

Question 8

MC presentation of portal vein obstruction

Answer 8

Bleeding from esophageal varices

Question 9

2nd most common presenting feature of portal vein obstruction

Answer 9

Splenomegaly, sometimes with hypersplenism

Question 10

Hepatopulmonary syndrome develops in ≥10% of patients with cirrhosis and is defined as

Answer 10

PaO2 defect induced by intrapulmonary microvascular dilatation, resulting from the release of mediators such as NO into the venous circulation

Question 11

Flow through the portal vein associated with variceal bleeding

Answer 11

Hepatofugal flow

Question 12

Most reliable method for detecting esophageal varices and for identifying source of GI bleeding

Answer 12

Endoscopy

Question 13

MOA of vasopressin in variceal bleeding

Answer 13

Increases splanchnic vascular tone thus decerasing portal blood flow

Question 14

TIPS involves placing a stent between the

Answer 14

Right hepatic vein and right or left branch of the portal vein