Ch. 343 - Acute Appendicitis Flashcards
MC acute surgical condition in children
Acute appendicitis
Mainstay of treatment of acute appendicitis
Prompt appendectomy
T/F Incidence of appendicitis increases with age
T
Appendicitis is diagnosed in ___% of children presenting to the ER for evaluation of abdominal pain
1-8%
T/F Mortality rate of acute appendicitis is high
F, low, less than 1%
T/F Morbidity rate of acute appendicitis is high
T
T/F Children have a higher perforation rate of appendicitis than adults
T, 82% for children younger than 5, approaching 100% in infants
Complications brought about by acute appendicitis
1) Perforation 2) Abscess formation 3) Peritonitis 4) Pylephlebitis (due to bacterial invasion of mesenteric veins to involve the portal vein and SMV) 5) Thrombosis 6) [Fistula formation>] Liver abscess and abscess formation in adjacent organs 7) Scrotal cellulitis and abscess through a patent processus vaginalis (congenital indirect inguinal hernia) 8) Small bowel obstruction
Final common pathway of appendiceal inflammation and its complications
Invasion of the appendiceal wall by bacteria
Factors implicated in the initiation of acute appendicitis
1) Luminal obstruction 2) Enteric infection 3) Blunt abdominal trauma 4) Cystic fibrosis (due to abnormally thickened mucus)
Implicated in luminal obstruction that leads to acute appendicitis
1) Inspissated fecal material 2) Lymphoid hyperplasia 3) Ingested foreign body 4) Parasites 5) Tumors (e.g. carcinoid tumors of the appendix)
Pathophy of acute appendicitis caused by luminal obstruction
Luminal obstruction > bacterial proliferation and continued secretion of mucus > elevated intraluminal pressure > lymphatic and venous congestion and edema > impaired arterial perfusion > ischemia of wall of appendix > bacterial invasion of appendiceal wall > necrosis
Clinical disease progression of appendicitis
Simple appendicitis > gangrenous appendicitis > appendiceal perforation
Acute appendicitis is most common at what age group
Teenagers/older children/specifically between 12 and 18 years old (less than 5% of cases in less than 5y/o, less than 1% of cases in less than 3 y/o)
Why is acute appendicitis most common during teen years
Submucosal lymphoid follicles, which can obstruct appendiceal lumen, are few at birth but multiply steadily during childhood and peak in number during teen years
T/F Majority of specimens from cases of acute appendicitis demonstrate luminal obstruction
F, less than 50%
Pathophy of acute appendicitis caused by enteric infection
Mucosal ulceration > invasion of the appendiceal wall by bacteria
Organisms implicated in acute appendicitis
Yersinia, Salmonella, Shigella, infectious mononucleosis (EBV), mumps, coxsackie B, adenovirus, Ascaris
T/F Appendicitis is common in neonates
F, RARE, hence occurrence warrants diagnostic evaluation for CF and Hirschprung disease
“A primary focus in the management of acute appendicitis is
Avoidance of sepsis and infectious complications
Why is “Avoidance of sepsis and infectious complications” a primary focus in the management of acute appendicitis
Leads to increased morbidity
T/F Bacteria can be cultured from the serial surface of the appendix before microscopic or gross perforation
T
Localized abscess or inflammatory mass formed subsequent to perforation by the momentum and adjacent loops of bowel
Phlegmon
Reason why young children are often unable to control local infection
Poorly developed omentum
T/F Classic presentation of acute appendicitis represents majority of acute appendicitis cases in children
F, less than 50%; majority are atypical
Acute appendicitis in children typically begins with
Generalized malaise and anorexia
Appendiceal perforation in children is likely to occur within
48 hours of onset of illness