Portal hypertension Flashcards
What is the normal blood pressure in the portal venous circulation?
3-5mmHg
At what pressure is portal hypertension diagnosed?
> 6mmHg
At what pressure do varices develop?
> 8mmHg
At what pressure do varices bleed?
> 12mmHg
Name common sites for varices to occur
Esophago-gastric
Peri-umbilical
Retroperitoneal
Rectal
Name the causes of portal hypertension
- Pre-hepatic
- Hepatic
- Post-hepatic
Name pre-hepatic causes of portal hypertension
Schistosomiasis (adults)
Portal vein thrombosis (children)
Name hepatic causes of portal hypertension
Hepatitis B Hepatitis C Alcohol liver cirrhosis NASH Wilson's disease
Name post-hepatic causes of portal hypertension
Budd-Chiari syndrome
Hepatopulmonary syndrome
What is the clinical presentation of portal hypertension?
Variceal bleeding
- haematemesis
- PR bleeding
Discuss the management of portal hypertension?
Resus Somatostatin analogue PPI Prophylactic antibiotic Bloods (FBC, U+E, LFT, INR) Child-Pugh score Treat the cause Emergency portosystemic shunt if bleeding does not stop Lifelong non-selective beta blockers
Name somatostatin analogues?
Octreotide
Somatostatin
Terlipressin
What is the role of somatostatin analogues in the management of portal hypertension?
Decrease splanchnic blood flow
What is the role of PPIs in the management of portal hypertension
Increase gastric pH
Blood clot stabilization
Discuss the management of oesophageal varices
Endoscopy
- rubber band ligation
- injection sclerotherapy
- SEMS
- Sengstaken Blakemore tube