Portal hypertension Flashcards

1
Q

What is the normal blood pressure in the portal venous circulation?

A

3-5mmHg

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2
Q

At what pressure is portal hypertension diagnosed?

A

> 6mmHg

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3
Q

At what pressure do varices develop?

A

> 8mmHg

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4
Q

At what pressure do varices bleed?

A

> 12mmHg

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5
Q

Name common sites for varices to occur

A

Esophago-gastric
Peri-umbilical
Retroperitoneal
Rectal

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6
Q

Name the causes of portal hypertension

A
  1. Pre-hepatic
  2. Hepatic
  3. Post-hepatic
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7
Q

Name pre-hepatic causes of portal hypertension

A

Schistosomiasis (adults)

Portal vein thrombosis (children)

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8
Q

Name hepatic causes of portal hypertension

A
Hepatitis B 
Hepatitis C
Alcohol liver cirrhosis
NASH 
Wilson's disease
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9
Q

Name post-hepatic causes of portal hypertension

A

Budd-Chiari syndrome

Hepatopulmonary syndrome

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10
Q

What is the clinical presentation of portal hypertension?

A

Variceal bleeding

  • haematemesis
  • PR bleeding
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11
Q

Discuss the management of portal hypertension?

A
Resus 
Somatostatin analogue 
PPI
Prophylactic antibiotic
Bloods (FBC, U+E, LFT, INR) 
Child-Pugh score 
Treat the cause
Emergency portosystemic shunt if bleeding does not stop 
Lifelong non-selective beta blockers
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12
Q

Name somatostatin analogues?

A

Octreotide
Somatostatin
Terlipressin

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13
Q

What is the role of somatostatin analogues in the management of portal hypertension?

A

Decrease splanchnic blood flow

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14
Q

What is the role of PPIs in the management of portal hypertension

A

Increase gastric pH

Blood clot stabilization

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15
Q

Discuss the management of oesophageal varices

A

Endoscopy

  • rubber band ligation
  • injection sclerotherapy
  • SEMS
  • Sengstaken Blakemore tube
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16
Q

Name types of portosystemic shunts

A

Non-selective

Selective

17
Q

Name complications of portosystemic shunts

A

Post-shunt encephelopathy (selective

18
Q

Name indications for variceal surgery

A
  1. Ongoing variceal bleeding despite intervention
  2. Recurrent variceal bleeding
  3. C/I for non-selective beta blockers
  4. Access to care