Neonatal jaundice Flashcards
1
Q
When is jaundice pathological?
A
<24h
Lasts >14 days
Pale stools
2
Q
Give a differential diagnosis for neonatal unconjugated hyperbilirubinemia
A
Haemolytic
- ABO incompatibility
- Rh incompatibility
- infections
- G6PD deficiency
- pyruvate kinase
- spherocytosis
- sickle cell
- thalassemia
Non-haemaolytic
- physiological jaundice
- polycythaemia
- maternal diabetes
- breast milk jaundice
- hypothyroidism
- ITP
- Crigler-Najjar
- Gilbert
3
Q
Give a differential diagnosis for neonatal conjugated hyperbilirubinemia
A
Infections: TORCHES UTI Hepatitis B/c HIV Neonatal hepatitis
Structural
- biliary atresia
- choledochal cyst
- IBD hypoplasia
- hepatic infarction
Metabolic
- galactosemia
- alpha-1 antitrypsin deficiency
- CF
- Alagille syndrome
4
Q
Name investigations in neonatal hyperbilirubinemia
A
TORCHES panel
Metabolic
U/S liver and biliary tree
LFTs
5
Q
How do you diagnose biliary atresia
A
GGT>1000 in presence of obstructive jaundice
Confirm with U/S
6
Q
Name the treatment of biliary atresia
A
Kasai portoenterostomy
Fails -> liver transplant
