Population Genetics Flashcards
What is genotype frequency ?
Number of individuals in defect / population
Allele frequency formula ?
Number of allele copies / 2* population
What are the 3 rules to apply hardy weinberg law in a population ?
No mutation
No migration
Large population
What is the difference between Stratified mating, Assortive mating and Consinguinous mating ?
Stratified - Religion and caste
Assortive - traits
Consinguinous - Relatives
What is genetic drift ?
Random mating with rare genotypes have more effect in allele frequency in small population
What is founder effect ?
Population restriction resulting in small population having different allele frequency
What is fitness of mutations?
Offspring of individuals affected by a specific condition
What is genetic lethal ?
No reproduction
What is coefficient of selection ?
S=1-F
What are the three types of Tay Sachs?
Type 1- Alpha subunit
Type 2 (Sandhoff) = beta subunit
Type 3 = activator deficiency
What are the CF Of Tay Sachs ?
Loss of vision hearing and movements
Neural degeneration
Cherry red fovea centralised
Death at 2-5 years
What mutation causes Gauchers disease ?
Mutation in G A encoding B-Glucocerebrosidase
