Pathology - Cell Signaling

Question 1

What are the 4 receptor catagories ?

Answer 1

GPCR
ION CHANNEL
RTK
NO INTRISIC RTK

Question 2

What are the 2 transmembrane receptors ?

Answer 2

GPCR
RTK

Question 3

What are the THREE pathways of RTK?

Answer 3

P13 KINASE
MAPK/RAS
IP3

Question 4

What are the 2 pathways of GPCR?

Answer 4

CAMP & IP3

Question 5

What is the difference between non receptor tyrosine kinase and RTK?

Answer 5

NON RTK- NO TRANSMEMBRANE
ONLY INSIDE CELL
CELL DIVISION AND GENE EXPRESSION

Question 6

What are the functional protiens in RTK?

Answer 6

GFR

Question 7

Does phosphorylation Activates or inactivates RTK?

Answer 7

Activates

Question 8

What is the function of GAP?

Answer 8

Convertes active GTP to Inactive GDP

Question 9

What does mutations in RTK cause?

Answer 9

Increases proliferation
Decreases GAP
Increases ACTIVE GTP without GFR

Question 10

What RTK mutation is most common elderly carcinoma?

Answer 10

Point mutation

Question 11

What does Inactivation of EGFR and ERB-B cause ?

Answer 11

MS AND ALZHIMERS

Question 12

Overactive EGFR causes?

Answer 12

Breast cancer and lung adenocarcinoma

Question 13

Genes responsible for Breast cancer ?

Answer 13

HER2/NEU (ERBB-2)

Question 14

Genes responsible for lung adenocarcinoma ?

Answer 14

ERBB1

Question 15

Genes responsible for tumour angiogenesis ?

Answer 15

VEGFR

Question 16

RET receptor mutation causes ?

Answer 16

MEN 2A & MEN 2B
(FAMILIAL MEDULLARY THYROID CARCINOMA)