Pathology Cell Cycle And Oncogenes

Question 1

What are the 3 mechanisms of oncogenes ?

Answer 1

Point mutation
Translocation
Amplification

Question 2

What point mutation causes 90% of pancreatic cancer and 50% of colon and thyroid ?

Answer 2

KRAS MUTATION

Question 3

What is Philadelphia chromosomes ?

Answer 3

Translocation of ABL gene from chromosomes -9 to 22 and forming.

BCR-ABL

Question 4

What are the Disorders related to translo of chromosomes.?

Answer 4

A B C E R F S

Acute Promylotic leukemia - 15:17
Burkif : 8:14
CML : 9:22
Ewings : 11:12
Renal : X:11
Synovial : X:18
Follicular : 14:18