Pathology 14- Invasion And Metastasis

Question 1

What is Metastasis ?

Answer 1

Spreading of new tumours

Question 2

What is angiogenesis ?

Answer 2

New blood vessels formation

Question 3

What is extravasation?

Answer 3

Leakage of blood or lymph

Question 4

What are the multiple steps of Metastatic cascade ?

Answer 4

Invasion of ECM
Lymph or vascular Invasion
Angiogenesis
Extravasation
Colonization

Question 5

How do cancer cells degrade ECM ?

Answer 5

By using Metamelanoproteasea MMP

Question 6

What organ does carcinoma and sarcoma affect ?

Answer 6

Carcinoma - lymph
Sarcoma - blood

Question 7

What does favorable soil mean in Metastasis ?

Answer 7

Organs with rich blood supply
Lungs

Question 8

How does tumour target specific organs ?

Answer 8

Chemokines
Tumour angiogenesis

Question 9

How do you differentiate between primary cancer and Metastatic cancer using leisons.?

Answer 9

Single leison - Primary cancer
Multiple leison - Metastasit cancer

Question 10

Which part of the lymph node does cancer origin ?

Answer 10

Subcapsular