Genetic Linkage Flashcards
What is homologous recombinant?
Crossing over during prophase 1
What are the chances of parental and non parental chromosomes in independent assortment ?
50%
50%
When is the recombination lesser?
When the genes are tightly linked and closer together
What is the unit of physical distance between genes ?
MB
What is unit of genetic distance of genes ?
Frequency of recombination %
What is theta in genetic linkage ?
It is recombination frequency
When theta is 0 = tightly linked
When theta Is 0.5 = u liked (independent assortment)
What are Hotspot in genetic linkage ?
Loci at which recombinant occurs at high frequency.
Tightly linked
What are the 3 analysis used in genetic linkage ?
Linkage analysis
Association analysis (Population)
Genome sequence ( whole exome or Genome)
What is log of odds score?
To determine of there is linkage present or not
How do you derermine the linkage using LOD score (Z)
+ve = linkage
-ve = no linkage
More than 3 = reliable
Less than -2 = reliable
In between = not reliable
What is the difference between theta and (Z) in genetic linkage ?
Theta = the frequency of recombination
(Z) = precence of linkage
What are haplotypes in genetic linkage ?
Set of alleles from different polymorphic loci that occur together on one chromosome
What is linkage disequilibrium ?
Haplotypes are unpredictable
Occur more or less
Alleles are close and linked
What is haplotype analysis ?
Used to define boundaries of disease associatied gene containg regions
