Multifactorial Disorders Flashcards
What are the two factors of multifactorial Disorders ?
Genetic and environmetal
Most common disease are in which part of the graph in multifactorial Disorders ?
In the middle
Does Multifactorial Disorders follow mendilian pattern of inheritance ?
No
What are the penetrance levels of individual genes in multifactorial Disorders ?
Low
Is Multifactorial Disorders a quantitative trait ?
Yes
How does Multifactorial Disorders graph look like ?
Smooth
Normal distribution
Are liabilities of multifactorial Disorders Additive ?
Yes
Can liabilities be measured in a individual or a group ?
A group
When is a multifactorial Disorders expressed in order to threshold traits ?
Above threshold - severity of Disease
Below - Not expressed
What are the types of Multifactorial Disorders studies ?
Population / Migration studies
Adoption studies
affected family studies
Case control studies
Twin studies
What are the factor frequency in adoptive family ?
Environment factors
What are the factors of frequency in a biological family.?
Genetic effects
How does the clustering in a proband affect in a affected family studies ?
Closer the relation more the risk and clustering
What is the formula of Sibling risk ratio?
Prevelance of disease in sibling of affected / Prevelance jn general population
How do you confirm if the diseases is genetic or environmental by using Sibling risk ratio ?
Ratio = 1 ( No genetic)
Ratio = more than 1 (genetic)
What is concordance ?
When two related individual share a trait
How do you derermine the factor by using concordance ?
Full MZ concordance = genetic
MZ>DZ = GENETIC
LESS THAN 100% MZ or DZ = non genetic
What is the formula of Heritability ?
H’2 = varaince in DZ - Varaince in MZ/ VARIANCE IN DZ
If H’2 = 1 ( only genetic)
If H’2 = 0 (environment)
