Polypharmacy Flashcards
1
Q
What is poly pharmacy?
A
Taking >4 medications
2
Q
Which part of the processing of drugs does CYP450 occur in
A
Liver phase 2 metabolism
3
Q
Absorption changes as you age
A
- Decreased acid secretion
- Decreased GI motility and BM
- Increased mucosal atrophy
- Decreased drug transport
4
Q
Distribution changes as you age
A
- Increased body fat and reduced muscle mass
- Decreased cardiac output
5
Q
Metabolism changes as you age
A
- Decreased hepatic blood flow
- Decreased enzyme activity
- Drug interactions
6
Q
prescribing cascade
A
- Pt given one medication
- Pt experiences adverse reactions
- Rather than review medication, pt given another medication
- Cycle continues
7
Q
Consequences of poly pharmacy
A
- Pill burden
- Pt confusion
- Poor concordance
- Drug interactions
- Increased ADRs
8
Q
why do patients stop taking medications?
A
- Intentional - no motivation, lack of understanding, ADRs, worries
- Unintentional - forgetfulness, practical difficulties
9
Q
orphan drug
A
A drug seemingly without a causative disease
10
Q
Orphan disease
A
A disease with no treatment
11
Q
Common drugs causing problems in elderly
A
Anti- drugs
e.g. convulsants, depressants etc
