polycystic kidney disease Flashcards
1
Q
autosomal dominant polycystic kidney disease have a risk of
A
Cyst rupture
Cyst infection
CKD
Subarachnoid haemorrhage due to aneurysm
Intracerebral haemorrhage due to hypertension
2
Q
caused by what gene mutations
A
PKD1gene on chromosome 16 or PKD2 on chromosome 4
3
Q
symptoms and signs
A
Renal:
Flank pain and haematuria
Patients may present with flank pain, fever and urinary symptoms if they have a cyst infection
Hypertension
Renal failure (slowly progressive CKD)
Extra-renal:
Extrarenal cysts e.g. liver, pancreas, spleen
Intracranial berry aneurysms commonly at the junction of the anterior communicating artery and anterior cerebral artery
Mitral valve prolapse, aortic regurgitation
Diverticular disease
4
Q
investigations
A
US
CT and MRI to determine extent of cystic disease
