Plasma Glucose: Glucagon (lec 27)

Question 1

Goal of Glucagon?

Answer 1

↑ blood glu (mobilization of fuels)

also ↑ FFA and ketoacids
↓ plasma AA

Question 2

Glucagon storage?

Answer 2

granules

Question 3

Glucagon secreted from?

Answer 3

pancreas ⍺ cells

Question 4

Glucagon secretion regulation?

Answer 4

↓ glu (fasting state) or AA -> glucagon secretion

Question 5

Glucagon primary target?

Answer 5

liver

Question 6

Glucagon action on liver?

Answer 6

↑ gluconeogenesis
↑ glycogen breakdonw
↓ glycogen synth
↑ glucose release
↑ FA oxy -> ketone bodies

Question 7

Glucagon action on adipose tissue?

Answer 7

↑ FA release

Question 8

Glucagon relationship to Incretin Effect?

Answer 8

proglucagon Δ to GLP1 in intestines ->

↑ insulin secretion w/ meal

Question 9

Somatostatin synth where?

Answer 9

pancreas delta cells, hypothalm, GI tract

Question 10

Somatostatin actions on metabolism?

Answer 10

↓ insulin/glucagon secretion

↓ GH secretion

Question 11

Cortisol actions on metabolism?

Answer 11

↑ gluconeogenesis -> ↑ blood glucose

Question 12

GH actions on metabolism?

Answer 12

Carb metabolism:
↓ glucose uptake/use by mm, liver, adipose
↑ gluconeogenesis

Plasma GH ↑ in BOTH fed and fast states

Question 13

Catecholamines actions on metabolism?

Answer 13

mobilizes fuel during stress:
↑ glycogenolysis
↑ gluconeogenesis