Plasma Glucose: Fasting/Feeding Flashcards
Abundance of Food causes what metabolic state?
Anabolic/Growth
Anabolic/Growth State relationship to plasma GH levels?
GH levels ↑
Scarcity of Food causes what metabolic state?
Catabolic/Glucose Sparing
Catabolic State relationship to plasma GH levels?
GH levels ↑
Fasting causes what 4 things to increase?
Increase of these things results in what?
glucagon
cortisol
epi
GH
liver glucose production
GH in fasting state causes what 2 things to decrease?
IGF (insulin growth factor)
insulin
High protein intake affect β cells how?
Can result in?
stimulates β cells -> ↑ insulin -> ↑ protein synth, ↑ glucose uptake by cells, ↓ glucose output by liver
Can result in hypoglycemia
High protein intake affects ⍺ cells how?
Can result in?
stimulates ⍺ cells -> ↑ glucagon -> ↑ glucose output by liver
Can results in hyperglycemia
Hypoglycemia prevented during high protein intake by what 2 things?
GH and glucagon
High protein intake results in increase of what?
↑GH results in?
↑insulin and ↑GH -> ↑IGF -> ↑protein synth, ↑lean body mass
↑GH -> ↑glucagon but ΦΔ in calorie storage
High carb intake results in?
↑ incretin -> ↑ insulin -> ↓ GH -> ↑ caloric storage
ΦΔ in IGF, protein synth, growth
Φ glucagon response cuz no AAs
Glucose infusion affects glucoregulatory hormone response to exercise how?
↓
During the first few minutes of exercise, energy is pulled from?
glycogen and glucose (ATP then anaerobic)
During extended exercise, energy is pulled from?
FFA (aerobic oxidation)
IL-6 is?
Does what?
myokine
↑ glucose uptake/FA oxid in skeletal mm
↑ glucose production in liver/lipolysis in adipose
What happens to insulin during exercise?
↓ by catecholamines (SNS)
glucose infusion will NOT override
Glucose uptake during exercise facilitated by?
contraction of skeletal mm
What happens to glucose levels during intense acute exercise?
mm use stores glucose first then catecholamines stim large release of glu from liver (large ↑ in plasma glu level)
Stim of insulin activation receptors causes what?
recruitment of GLUT4 transporters to surface of cells -> pull glucose into cell