Plasma cell myeloma and monoclonal gammopathy of uncertain significance Flashcards
the most common (known) premalignant condition
Monoclonal Gammopathy of Uncertain Significance
Diagnostic criteria for MGUS
serum M-protein…
MGUS Mayo criteria risk factors
Non-IgG M-spike, M-spike>15g/l, abnormal serum…
Myeloma is always preceded by MGUS true or false
true
Most people with MGUS will develop myeloma true or false
false
Pathogenesis of multiple myeloma
bone destruction, angiogenesis, anaemia, and immunosuppresion and infection
Diagnostic criteria of multiple myeloma
CRAB. C: Hypercalcaemia - calcium > 2.75mmol/L R: renal disease - creatinine > 177 micromol/L orr eGFR < 40ml/min A: anaemia Hb<100g/L, drop by 20g/L B: bone disease
Clinical presentations of bone disease in multiple myeloma (80% of patients)
Proximal skeleton; back, spine, chest wall, pelvic painl osteolytic lesions; osteopenia ………
Imaging for myeloma bone disease
Whole body CT scan low-dose, CT/FDG-PET scan, or whole body diffusion-weighted MRI (bone marrow cellularity and active vs. treated disease)
Which is the most COMMON cytogenetic abnormality in myeloma?
Hyperdiploid karyotype
Causes of myeloma kidney disease:
cast nephropathy caused by high serum free light chains (FLC) levels) … Bence Jones Proteins…?
What us the cornerstone of myeloma kidney disease treatment??
….
Myeloma diagnostic workup
Immunoglobulin studies, bone marrow aspirate and biopsy, FISH analysis, flow cytometry immunophenotyping
What is a key histopathological myeloma marker?
CD138
The amyloidogenic potential light chains is less important then their amount true or false
false
