CNS infections and meningitis

Question 1

Pathogenesis - 4 routes of entry to CNS

Answer 1

A) haematogenous spread
B) direct implantation
C) local extension
d) PNS into CNS

Question 2

Meningitis

Answer 2

inflammatory process of eninges and CSF

Question 3

meningo…

Answer 3

inflammaion of meninges and brain parenchyma

Question 4

meningitis neurological damage by:

Answer 4

direct bacterial toxicity,

indirect inflammatory process and cytokine release and oedema,

shocks, seizures, cerebral hypoperfusion,

mortality ~
morbidity

Question 5

classification of meningtis

Answer 5

acute, chronic, septic

Question 6

meningococcal meningitis classification… acute, chronic or aseptic?

Answer 6

acute

Question 7

Acute meningitis exmaples

Answer 7

usually bacterial - NHS??
*Neisseria meningitidis, *streptococcus pneumoniae, *haemophilus influenzae, listeria monocytogenes, group B streptococcus, escherichia coli

Question 8

Chronic

Answer 8

Usually TB, spirochetes, cryptococcus

Question 9

Aseptic

Answer 9

Viral

Question 10

Chronic tuberculosis meningtis incidence

Answer 10

544 per 100,000 in africa

Question 11

mortality

Answer 11

5.5 deaths per 100,000

Question 12

what can chronic meningitis cause?

Answer 12

TB meningitis?

Question 13

Aseptic meningtis is most common infection of CNS ?

Answer 13

True

Question 14

features of aseptic meningtis

Answer 14

headache, stiff neck, photophobia, nonspecifc rash

Question 15

what are aseptic meningitis caused by

Answer 15

enteroviruses (cocksackievirus group B and echovirus) …

Question 16

What virus is a leading cause of encephalitis internationally?

Answer 16

West Nile virus

Question 17

Most common form of vertebral infection

Answer 17

pyogenic vertebral osteomyelitis

Question 18

Spinal infections RF

Answer 18

Advanced age, IV drug use ….

Question 19

investigations for meningitis

Answer 19

MRI superior to CT scanning. CSF sample. blood culture.