Plant Depressants: Alcohol Flashcards

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1
Q

How is ethanol made?

A

Through fermentation of sugars by Saccharomyces cerevisiae.

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2
Q

What are Yeasts?

A

Yeasts are unicellular fungi that reproduce colonially by budding (asymmetric mitotic division).

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3
Q

What is Brewer’s yeast used for and how does fermentation work?

A

Brewer’s yeast will convert sugars to CO2 and alcohol in a process known as fermentation, and is used commercially for both baking and alcohol production.

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4
Q

What is the difference in yeast strains used in baking versus alcohol production?

A

Baking: Rapidly dividing strains are preferred since they carbonate bread dough quickly.
Alcohol: Grow more slowly, tolerate much higher amounts of alcohol and produced fewer secondary waste products.

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5
Q

What is the larger yeast (S. pastorianus) used to produced and how does it grow?

A

The larger yeast is a slow growing strain and has adapted to lower temperatures and is used to produce large beer.

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6
Q

What was large yeast long thought to be a hybrid strain of until recent evidence was found suggesting that S. eubayanus, a wild species native to Patagonia is likely a parent?

A

S. cerevisiae.

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7
Q

What does yeast fermentation involve?

A

The anaerobic breakdown of sugars to ethanol and carbon dioxide.

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8
Q

Where is the sugar source in alcoholic beverage production generally from?

A

High sucrose fruits (grapes), or malted grains (usually sprouted barley grains which retain the amylase enzyme required to convert starch to sugars).

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9
Q

How does alcohol tolerance vary among strains?

A

Beer yeasts generally tolerate about 6% alcohol, whereas many strains of wine yeast can tolerate up to 16% alcohol.

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10
Q

What are the three major groups of alcoholic beverages?

A

Beer (barley), wine and cider (fruit), and mead (fermented from honey).

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11
Q

What were the earliest wines like?

A

They were naturally fermented from wild grapes and low in alcohol and high in acetic acid (vinegar).

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12
Q

Where and when does evidence exist from the first ever wine production?

A

Residue in pottery jars in Persia and southern Caucasus about 7000-8000 years ago, and Eastern Europe (Balkans) 6000 years ago.

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13
Q

By when was the grape vine fully domesticated and large scale wine production common in these regions?

A

5000 BP.

Beer at the same time.

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14
Q

What type of tablets (5000 BP) include recipes for making beer from wheat and barely?

A

Babylonian.

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15
Q

In what way did the ancient Egyptians revere wine and beer?

A

They believed them to be nutritious beverages and medicines and both were used in ritualistic ceremonies and funeral rites.

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16
Q

When does evidence of fermented beverages made from rice, honey and fruit in China date back to?

A

7000-8000 years ago.

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17
Q

What type of “beer”, then known as wine was produced throughout east Asia?

A

Cooked rice was fermented to produce “wine” (beer since rice is cereal) and sake.

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18
Q

How was rice wine prepared?

A

The rice was chewed prior to fermentation with saliva providing the enzymes necessary to convert starch into sugars.

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19
Q

What did the Inca produce?

A

A corn based ceremonial alcoholic beverage known as chichi de jora in large pottery vats.

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20
Q

What did the Mayans produce?

A

A sacred, milky alcoholic beverage from honey and bark from the leguminous balche tree.

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21
Q

What was the result religious significance of the balche tree?

A

It was banned by the conquering Spaniards due to its religious ties.

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22
Q

What was made in Central America and how long has it been produced?

A

Pulque (octli), an alcoholic beverage fermented from Agave stems, and has been produced for at least 2000 years.

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23
Q

Who worshipped a wine goddess and various wine deities?

A

Babyloninans (4500 BP).

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24
Q

Which text describe the medical benefits of sura (a fermented beverage of rice, wheat, sugar cane, grapes and other fruit) when used in moderation?

A

Indian Ayervedic texts (4000 BP)..

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25
Q

What does the Egyptian papyri (4000 BP) discuss the medicinal use of alcohol as?

Greeks and Romans also used alcohol for therapeutic purposes.

A

1) Tranquilizer
2) Analgesic
3) Soporific
4) Recommended for delivering other medicines (many plant based drugs are soluble in alcohol).

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26
Q

What was alcohol recommend to remove?

A

Irritant piles (poison ivy), to relief sore muscles (as rubbing alcohol will cool the skin), and as a disinfectant and as an anesthetic (heavy drinking prior to painful surgery or amputation).

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27
Q

Who recognized the deleterious effects of alcohol?

A

The early Hebrew and Ayurvedic cultures and later in Ancient Greece and Rome.

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28
Q

Who was the Middle East under the control of in the 7th century and how did this affect wine drinking?

A

Muslim control, and despite Islamic prohibition on drinking, the region continued with wine.

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29
Q

What does the Qur’an state in regard to alcohol?

A

Intoxicants of any kind are generally forbidden in the Qur’an and alcohol is considered an abomination that discourages prayer and turns worshippers from God.

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30
Q

Along with muslims, who else abstain from alcohol?

A

Buddhists, Hindus, and Sikhs.

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31
Q

What was Christianity’s viewpoint on alcohol?

A

Viewed it as a divine gift from God, to be used for its beneficial medicinal and tranquilizing effects although overindulgence was a sin.

32
Q

What drink did the Greece originally drink (4000 yrs ago), and what did they drink later (3700 yrs ago)?

A

Mead to wine.

33
Q

How was wine used in the ancient greeks?

A

Used in religious rituals and for medical purposes and was taken as part of daily meal.

34
Q

Who was the god of grape harvest and winemaking in Greek times?

A

Dionysus.

35
Q

Who established the wine producing regions in soother Europe?

A

Ancient greeks and Romans between 3000 and 2000 years ago.

36
Q

What occurred in regard to wine at the height of the Roman Empire?

A

Wine became a part of the Roman diet, new grape varieties were developed, methods of grape cultivation were improved, and modern method of wine making and storage were developed.

37
Q

Who inherited the wine making tradition of the Roman Empire when it fell in 476?

A

The Catholic Church and controlled Europes vineyards for the next 1300 years.

38
Q

What was beer known as in the Middle Ages?

A

Aqua vitae (the water of life), as it provided important calories, vitamins, and minerals-was also a potable beverage since its preparation involved boiling of water.

39
Q

Who perfected the addition go hops (fruit from Humulus lupulus) to preserve and flavour beer in the 13th century?

A

Germany.

40
Q

What were the two main types of beer brewed?

A

Ales and Lagers.

41
Q

What is the difference between Ales and Lagers?

A

Ales are fermented quickly using top-fermenting Brewer’s yeast, and have a sweet, fruity taste, whereas lagers are fermented slowly and at low temps using bottom ferment yeast.

42
Q

Where was lager invented?

A

Germany.

43
Q

What was the beer in medieval Europe that acted highly nutritious with just enough alcohol to act as a preservative and antiseptic.

A

Small beer.

44
Q

In the 17th century, what was the consumption of beer in England northern Europe?

A

300 L a person.

45
Q

What is the maximum alcohol content of fermented beverages?

A

16%, reflecting the ethanol tolerance of yeast strains used in fermentation.

46
Q

Who developed distillation that was introduced to Europe via Salerno medical school about 200 years later?

A

Arab alchemists, boils lower than water therefore will contain higher concentrated alcohol.

47
Q

What was the first printed book devoted exclusively to the art of distillation?

A

Liber de arte distillandi by Hieronymus Brunschwig.

48
Q

Which alchemists distilled wine into brandy and beer into whisky primarily for medicinal purposes?

A

Arab and European alchemists.

49
Q

How was alcohol used medically?

A

Was the tranquilizers while herbs were added for medicinal purpose.

50
Q

In 1500s, which drink added juniper berries to help medicinally?

A

gin.

51
Q

Where did the non-medical use of distilled beverages increase following the passing of the “act of encouraging distillation of brandy and spirits from corn” in 1960?

A

England.

52
Q

Why was the “act of encouraging distillation of brandy and spirits from corn” put in place?

A

To encourage the utilization of surplus grain supplies and to provide a source of government revenue by taxing distilled beverages.

53
Q

What was the alcohol production in England over the years?`

A

Gin doubled (2 million) in 1714, and over 11 million in 1734, and 18 million gallons by 1743.

54
Q

What was the English Gin Craze (first half of the 18th century), driven by?

A

By a cheap and abundant supply of gin, but social pressures of urbanization and a general acceptance of public drunkenness played a role.

55
Q

What did the recognition of issues associated with drunkenness lead to?

A

Legislation limiting sales and increasing taxes on gin in 1734- consumption continued to increase.

56
Q

What ended the Gin Craze?

A

A combination of higher grain prices, increased taxation of gin and other spirits, a temporary ban on distilling, cheaper good quality beer, and increases consumption of tea and coffee.

57
Q

Where and when did attitudes toward the consumption of alcohol begin to change and why?

A

In 19th century Europe, because of industrialization and the need for a reliable work force.

58
Q

What did 19th century Europe believe to be tied to alcohol consumption?

A

Excessive alcohol consumption was thought to contribute to high rates of urban crime, poverty and infant mortality, and social factors.

59
Q

_______ movements, advocated for reduced use or full prohibition of alcohol.

A

Temperance movements.

60
Q

Where and when were alcohol prohibition laws enacted?

A

Finland and Norway (20th century), and US (18th century) following amendment of American constitution.

61
Q

What did the US amendment prohibit?

A

The manufacture, sale and transportation of alcoholic beverages, therefore, highly lucrative alcohol manufacturing and smuggling operations developed in both Canada and Mexico to supply the insatiable American market.

62
Q

What is the principle psychoactive constituent of all fermented alcoholic beverages?

A

Ethanol.

63
Q

What is ethanol’s mode of action?

A

It affects many neurotransmission systems in the grain. It will stimulate receptors of gamma-amino butyric acid (GABA), the major inhibitory neurotransmitter of the CNS.
Ethanol is therefore a depressant, as it increases inhibitory affect of GABA.
However, also binds to acetylcholine, serotonin, and NMDA glutamate increasing dopamine levels by inhibiting an enzyme that breaks down dopamine.

64
Q

Which enzymes present in the stomach lining and liver catalyze the oxidation of ethanol to acetaldehyde, allowing for moderate consumption of alcoholic beverage?

A

Alcohol dehydrogenase (ADH).

65
Q

Is acetaldehyde toxic?

A

YES. More than alcohol but is rapidly converted to harmless acetic acid by acetaldehyde dehydrogenase enzyme.

66
Q

What is the elimination of alcohol (usually in the liver) considered?

A

A rate limiting step-(7-10mL metabolized per hour).

67
Q

What may increase the risk of alcoholism?

A

Slower metabolizing forms of ADH.

68
Q

What is ethanol classified as despite its initial effects of euphoria, talkativeness and relaxation (at 0.05% blood alcohol).

A

A depressant.

69
Q

What is CNA depression associated with art 0.1% blood alcohol level?

A

1) Nausea
2) Motor function impairment
3) Loss of self control
4) Vomiting
5) Delayed headache is associated with an allergic response to ethanol and other toxic substances present in alcoholic beverages as well as dehydration.

70
Q

What is the affect of blood alcohol levels about 0.14%?

A

Reduced blood flow to the brain and severe stupefaction (unconsciousness) occurring at 0.3%.

71
Q

When is death possible?

A

When blood alcohol level reaches 0.4% and is certain at levels of 0.55% or higher.

72
Q

What does alcohol adversely affect?

A

The production and activity of white blood cells (thus lowering the immune response) and can result in liver cirrhosis (loss of health liver cells and replaced by scar tissue) leading to weakness and chronic indigestion.

73
Q

What does heavy drinking damage?

A

The heart muscle, results in brain deterioration and is very harmful to a developing fetus.

74
Q

What do alcohol or ethanol withdrawal symptoms include?

A

Severe anxiety, autonomic dysfunctions (heart palpitations, fever, hypertension, incontinence), seizures and hallucinations.

75
Q

What percent of alcohol withdrawal patients experience delirium tremens (DT), the symptoms of which include autonomic dysfunction, confusion, disorientation, agitation, insomnia, shaking, and acute episodes of delirium and seizures?

A

5-10%.

76
Q

What are more physical symptoms of alcohol withdrawal?

A

1) Shivering
2) Sweating
3) Convulsions

77
Q

What happens by the fourth day of withdrawal?

A

Severe anxiety with a sense of impending doom are characteristic and visual hallucinations (peripheral field of vision), and a crawling sensation on the skin.