Plant Alkaloids Flashcards
1
Q
Microtubule disrupting plant alkaloids are agents that
A
inhibit polymerization of microtubules
2
Q
Vinblastine is a what?
A
M-phase inhibitor (metaphase arrest); inhibits tubulin polymerization
3
Q
What other plant alkaloids are there?
A
1) Vincristine and Vinorelbine
4
Q
What drug does the opposite of vinblastine/ vincristine/ venorelbine?
A
Taxanes: Paclitaxel and Docetaxel
5
Q
Paclitaxel & Docetaxel MOA:
A
cause polymerization of tubulin even in the absence of tubulin-assoc. proteins and GTP
