Antiretroviral Drugs- Fusion Inhibitors Flashcards
1
Q
Fusion inhibitors MOA
A
inhibit the attachment of, fusion of the virus with plasma membrane and entry into host cell
2
Q
Enfuvirtide MOA?
A
a synthetic 36 amino acid peptide that binds gp41 and prevents fusion of viral envelope with plasma membrane
3
Q
How is Enfuvirtide admin’d?
A
SC injections
4
Q
Adverse Reactions of Enfuvirtide?
A
injection site reactions, hypersensitivity, eosinophilia
5
Q
Maraviroc is a what?
A
chemokine receptor (CCR5) blocker
6
Q
Maraviroc is used specifically for…
A
CCR5 tropic R5 HIV infection that specifically targets CCR5 chemokine receptor
7
Q
What must be admin’d before giving Maraviroc?
A
Tropism test
8
Q
Resistance of maraviroc due to?
A
emergence of non-CCR5 tropic strains or mutations in gp120
