Anti-influenza Agents Flashcards
Influ viruses are classified based on…
core protein (A, B, C, etc), species of origin, geographic site
Influ B only infects…
humans
What influ virus causes pandemic?
Virus A
Influ classified based on surface antigen variants:
hemagglutinin (H) and neuraminidase (N)
What virus is endemic in SE Asia Poultry since 2003?
H5N1 bird virus
Swine flue pandemic caused by
H1N1
Amantadine & Rimantadine (aman derivative) MOA:
block M2 proton ion channel of the virus particle and prevent uncoating of the viral RNA within infected cells
Amantadine & RImantadine are only active against….
Influ A
Amantadine AE:
crosses the BBB, so CNS toxicity (nevousness, difficulty concentrating, insomnia)
Amantadine CNS effects may have to do with…
dopamine neurotransmission
Zanamivir & Osteltamivir are both
neuraminidase inhibitors and analogs of sialic acid (neuraminia acid)
Zanamivir & Osteltamivir MOA:
interfere with the release of progeny influenza viral particles from infected cells
Zanamivir & Osteltamivir are active against:
Both Influ A & B
Zanamivir & Osteltamivir administration…
early admin is CRUCIAL, within 36-48 hours
Prophylaxis of influ A & B?
Zanamivir & Osteltamivir
How is zanamivir admin’d?
Nasally or via inhalation
How is oseltmavir admin’d?
orally, bc its a prodrug
INF-a could also be used for treatment of…
condyloma acuminatum caused by HPV
RIbavirin can also treat…
respitory syncytial virus (RSV) in children via aerosol
Palivizumab can also be used to treat…
RSV (humanized monoclonal Ab)
Imiquimod can be used to treat…
HPV induced external genital and perianal condyloma acuminatum (warts)
