Anti-HEP Agents (HCV) Flashcards
1
Q
Current treatment plan for Chronic HCV:
A
once weekly PEG INF-a w/ combo of daily oral Ribavirin
2
Q
Treatment reduces viremia w/i
A
6 months after completion of therapy
3
Q
Ribavirin is what analog?
A
guanosine analog
4
Q
Ribavirin MOA:
A
phosphorylated by host cell enzymes, inhibits capping of viral mRNA, and also inhibits viral RNA-dependent DNA polymerase
5
Q
Ribavirin Adverse Reactions:
A
hemolytic anemia, depression, fatigue, irritability, rash, cough, insomnia, nausea and pruritus
6
Q
Ribavirin CI’d in
A
pregnancy, renal insuff, anemia, ischemia vascular disease
