PKPD Flashcards
1
Q
%T>MIC dependent drugs
A
- Penicillins
- Cephalosporins
- Carbapenems
- Macrolides
- Oxazolidiones
2
Q
Dosing goal for %T>MIC dependent drugs
A
- Prolonged infusion time
- Continuous infusion
- Shorter dosing interval
- Increase dose
3
Q
Cmax:MIC dependent drugs
A
- Aminoglycosides
- Quinolones
4
Q
Dosing goal for Cmax:MIC dependent drugs
A
- Extended interval dosing
- Maximize safe dose
5
Q
AUC:MIC dependent drus
A
- Vanco
- Azithro
- Tetra
6
Q
Dosing goal for AUC:MIC dependent drugs
A
Optimize safe dose
7
Q
Low vd and impaired Cl
A
Create high serum concentration
8
Q
High vd and augmented cl
A
create low serum concentration
9
Q
Changes to expect in the critically ill
A
- dec Cardiac output (dec cl)
- inc capillary leakiness (inc vd)
- AKI (hyperfiltration> inc cl)
- CKI (reduced renal cl)
10
Q
Abx w/o renal dosing adjustments
A
- Metro
- Azithro
- Nafcillin
- Tigecycline
- Oxacillin
- Linezolid
- Doxy
- Moxifloxacin
- Erythro
- Ceftriaxone
- Clinda
11
Q
Drugs that have rapid development of resistance
A
- Rifampin
- Clinda
- Quinolones (floxicin)
12
Q
Vancomycin target
A
AUC:MIC > 400 mg+h/L
13
Q
Vanco dosing
A
- old school (trough based; figure out Cl)
- AUC (non-Bayesian) - use peak/trough to calculate AUC
- AUC (Bayesian) -obtain random sample and previous knowledge and combine to get Cl
14
Q
Trough based dosing problems
A
Without the peaks there is no way to know what the area is exactly (neglects the area from the infusion)
15
Q
Two-point AUC dosing problems
A
- Partial miss of peak area
- Partial miss of infusion area
- Calculation intensive
