Hepatitis C

Question 1

Positive HCV test

Answer 1

Patient HCV status can not be determined w/o further testing for HCV RNA

Question 2

Acute HCV infection

Answer 2

Antibody does not confer immunity against subsequent infection

Question 3

Chronic HCV infection

Answer 3

Can spread infection to others

Question 4

Sofosbuvir

Answer 4

• Treats genotypes 1-4

- Can be used up to 48 weeks

Question 5

Sofosbuvir/Ledipasvir

Answer 5

• Approved only for genotype 1
• Duration: 12 weeks unless pt has cirrhosis use for 24 weeks
• Need CrCl: 30 ml/min

Question 6

Velpatasvir

Answer 6

• Treats genotypes 1-6

- Need CrCl > 30 ml/min

Question 7

Glecaprevir/Pibrentasvir

Answer 7

-Treats genotypes 1-6
-No cirrhosis > 8 wks, Cirrhosis (Pugh A) > 12 wks
Can not use if Child pugh score is C
-Appropriate in renal impairment

Question 8

Elbasvir/Grazoprevir

Answer 8

• Genotype 1: 12 wks
• Genotype 4: 12 wks
• Contraindicated in child pugh score of B or C
• Appropriate in renal treatment