COVID

Question 1

Remdesivir

Answer 1

• nucleoside base analog
• full approval for treatment
• dosing: 200 mg IV x1 then 100 mg IV qd for 5-10 days
• recommended for hospitalized patients with severe covid-19 and/or on supplemental o2 for 5 days
• 3 days for outpatients at high risk for progression to severe disease

Question 2

Dexamethasone

Answer 2

Dosing: 6 mg IV/PO qd for 10 days or until hospital discharge
-AE: hyperglycemia, agitation/confusion, adrenal suppression, risk of bacterial/fungal infection

Question 3

Tocilizumab

Answer 3

• Inhibits IL-6 binding to receptor > may prevent cytokine storm
• Dosing: 8 mg/kg IV
• AE: elevated LFTs, neutropenia, thrombocytopenia, infections
• indicated for hospitalized pts who are receiving systemic corticosteroids and require supplemental o2

Question 4

Baricitinib

Answer 4

• Modulates JAK signaling > anti-inflammatory; prevents viral entry into cells
• Dosing: 4 mg PO qd for 14 days or until hospital discharge
• AE: infections, thrombosis
• Elevated inflammatory markers
• patients on dexa + supplemental o2

Question 5

Neutralizing mAb

Answer 5

• Sotrovimab

- Dosing: 500 mg IV ASAP