Immunotherapeutics Flashcards
1
Q
Granulocyte-Monocyte colony stimulating factors
A
- Sargramostim
- Dose dependent inc in the production of neutrophils and monocytes
2
Q
Granulocyte colony stimulating factor
A
- Filgrastim
- Pegfilgrastim
- Affects primarily neutrophils
3
Q
Epogen and Procrit
A
Stimulates RBC maturation
4
Q
Predisposing factors to hypersensitivity rxns
A
- Fem>Males
- Adults>children
- Genetics
- Associated illness
5
Q
Type 1 rxn
A
- Anaphylactic
- Epinephrine
- Prevent a late phase rxn: methylprednisolone sodium succinate and diphenhydramine
6
Q
CNI DDI (Inhibition of CYP450)
A
- CCB
- Antifungals
- Abx
- PI
- Gastric acid suppressors
- Grapefruit juice
7
Q
CNI DDI (Induction of CYP450)
A
- Abx
- Antifungals
- Anticonvulsants
8
Q
Cyclosporine AE
A
- Hyperlipidemia
- Nephrotoxicity
- Tremor, HA
- Hypertension
9
Q
Tacrolimus AE
A
- Diarrhea, nausea
- Nephrotoxicity
- Tremor, HA
- Insomnia
10
Q
DDI w/ MPA (enterohepatic circulation)
A
- Cyclosporine inhibits MRP2 transporter
- Tacrolimus (minimal inhibition of MRP2)
- Cholestyramine and bile acid resins
- Abx reduced MPA AUC
11
Q
DDI w/ MPA (misc)
A
- Renal elimination (Acyclovir/Ganciclovir) (Co-trimoxazole)
- COC
- Protein binding (Phenytoin and ASA)
- Glucocorticoids
12
Q
Cortisone
A
25 mg
13
Q
Hydrocortisone
A
20 mg
14
Q
Prednisone
A
5 mg
15
Q
Methylprednisolone
A
4 mg
