PK-PD Flashcards
1
Q
Concentration Dependent
- Define
A
Increasing concentration provides best effect
2
Q
Time Dependent
- Define
A
Being over MIC provides best effect
3
Q
Concentration-Dependent Drugs
A
Fluoroquinolones
Metronidazole
Daptomycin
Aminoglycosides
4
Q
Concentration-Independent Drugs
A
Beta-Lactam
Glycopeptide
Macrolide
Clindamycin
Tetracycline
Linezolid
5
Q
Underdosing
A
Overweight Patients
High Volume of Distribution
Cystic Fibrosis
6
Q
Overdosing
A
Renal Dysfunction
Critically Ill
Older Age
7
Q
MSW
A
Mutant Selection Window
- Is between MIC (Least Susceptible) and MPC (Mutant Prevention Concentration)
Less time spent in this window means the less selection for mutants
8
Q
PK/PD Index
A
Beta-Lactams
- Time>MIC
Everything Else:
- AUC/MIC
Aminoglycosides:
- Cmax/MIC
