Carbapenams Flashcards
1
Q
Carbapenem
- Mechanism
A
- Gains entry to Gram-Negative bacteria through pores
- Bind to PBPs
- Resist Beta-Lactamase
- Resist penicillinase or cephalosporinase
2
Q
Carbapenem Resistance
- Mechanism
A
Change in OprD
Increased efflux
Change in PBP
Production of Carbapenemase Beta Inhibitors
3
Q
Imipenem/Cilstatin
A
Gram Positive + Gram Negative
- Imipenem is hydrolyzed into toxic molecules by Dehydropeptidase
- Cilstatin inhibits Dehydropeptidase
4
Q
Doripenem
A
Quite similar to Imipenem
- No hydrolysis
5
Q
Meropenem
A
Quite similar to Imipenem
- No hydrolysis
6
Q
Estapenem
A
Similar to Doripenem and Meropenem
No Pseudomonas Aeruginosa
No Actinobacter
7
Q
Aztreonam
A
Broad spectrum Gram-Negative
8
Q
Carbapenem
- Adverse Effects
A
Imipenem
- Seizures
Aztreonam
- Rash
- Increase Serum Transaminases
