Pig genetic diseases

Question 1

porcine stress syndrome aka MHS - malignant hyperthermia symdrome

Answer 1

heavy pigs are more likely to carry the gene, It includes acute stress and sudden death, poor meat quality (pale, soft, exudative PSE or dark firm dry meat DFD), halothane anasthesia sensitivity - malignant hyperthermia!

detected by halothane test, autosomal recessive, closure of Na⁺ channels in the mucle, intensive heat production, incr. meatabolism

Question 2

progressive myopathy

Answer 2

• lameness of piglets, muscular weakness

Question 3

tremor type 3

Answer 3

myoclonia = twitch, frequent muscle tremmor of piglets

Question 4

neonatal diarrhoea

Answer 4

piglets aged 0-4 days and can begin within 12 hours of birth. Affected piglets may suck but often stand with drooping tails, appear shrunken and have a dull skin with erect coat hairs. = dehydrated

Question 5

diagnosis of the PSS

Answer 5

(stress) monogenes can be partly diagnosed using PCR, in developed countries - to detect and eliminate the heterozygote. halothane in homozygote

Question 6

metabolic diseases

Answer 6

• *blood**: haemophilia A, pseudohaemoohilia (coag. cascade)
• *obesity genes**: genes, leptin, myogenin controlling fat…

Question 7

bone

Answer 7

vitamin D resistant rickets: low Ca²⁺ absorption resulting in growth disorders

​dwarfism: proportional, mutations of the GH receptor

Question 8

intersex diseases

Answer 8

XX males

(for. ovale persists)