Cattle genetic diseases

Question 1

BLAD

Answer 1

Bovine Lymphocyte Adhesion deficiancy - severe ulcers in oral mucous membranes, severe periodontitis(gum inflam.), loss of teeth, chronic pneumonia and recurrent or chronic diarrhea - die early caused by these complications

Question 2

haemostasis, blood circulation

Answer 2

protoporphyria: protoporphyrin accumilate in cell membr., absorb light making ROS ⇒ seizures, skin lesions
Platelet bleedingdisorder:
haemophilia B: insuficcient thrombin prod. ⇒ bleeding

Question 3

DUMPS

Answer 3

Deficiency of Uridine MP Synthase
diagnose by low enzyme act. in the blood. decr. DNA/RNA prod -> slow growth, leads to early embryonic death

Question 4

musclar diseases

Answer 4

• *muscular hypertrophy:** double muscling, cells multiply
• *spinal muscular atrophy:** little muscle

Question 5

skeletal

Answer 5

• *chondrodysplasia**: bone development disorder
• *achondroplasia**: leads to dwarfism
• *syndactylia**: fusion of digits

Question 6

atresia, agenesia

Answer 6

both lead to underdevelopment of organs:

• *kidney dysplasia:** malfunction of kidney
• *nephritis**: inflam. of the kidney

Question 7

intersexes - variation of sex characteristics

Answer 7

• *XY females, free-martin:** infertile female mammal with masculinized behavior and non-functioning ovaries
• *testicular feminisation:** Don’t react to androgens which are responsible for male characteristic maintinance and development. ⇒ hypoplasia

Question 8

goiter

Answer 8

in afrikaner cattle: enlarged thyroid gl. bc. hyper/hypothyroidism