PI3-Kinase

Question 1

What subunits does PI3-K have?

Answer 1

Regulatory (p85)

Catalytic (p110)

Question 2

PI3-K is recruited to_____________________.

Answer 2

Activated growth factor receptors.

Question 3

The p____ subunit contains a ____________.

Answer 3

85

SH2 domain

Question 4

The p______ subunit has __________________ activity specific for the 3 position of _______________________.

Answer 4

110
Lipid kinase
Phosphatidylinositol

Question 5

Requires__________ for _____ activation.

Answer 5

Ras/GTP

Full

Question 6

_________ counteracts the activity of PI3-K by dephosphorylating _________ to form _______.

Answer 6

PTEN
PIP3
PIP2

Question 7

PTEN is a_______________________.

Commonly called a ____________________

Answer 7

Lipid dependent phosphatase

Tumour suppressor

Question 8

Loss of PTEN activity is associated with a number of human tumours as ____________ remain _____________, mimicking __________________ signalling

Answer 8

Lipids
Phosphorylated
Growth factor

Question 9

A PH (_____________) means the molecule interacts with ________ in the _____________________.

Recruited via _____________________ to bring about ______________ in response to ______________.

Answer 9

Pleckstrin homology
Lipids
Plasma membrane

Phosphorylated lipids
Full activation
Growth factors