Cell Reg And Cancer: Simon Morley 5

Question 1

SH2 domains bind to___________is________long and has_________________________pockets. One for__________, the other provides__________

Answer 1

Phosphotyrosines
100 amino acids 
2 hydrophobic
Binding phosphotyrosine
Selectivity

Question 2

SH3 domains binds to________rich regions. Targeting sequence allows_______________________________. Critical in some proteins, allows________________.

Answer 2

Proline
Protein with SH3 domain to be moved to a target protein that’s rich in proline
Them to be turned on/off

Question 3

Inactive src on the inside of the PM is tied up because________________. In this confirmation___________________________.

Answer 3

Y527 interacts weakly with its own SH2 domain.

Nothing can get into the kinase domain.

Question 4

Src is a ________________________.

Answer 4

Phosphotyrosine kinase