Adrenaline Flashcards
__________ activates adenylate cyclase and makes cAMP. _________ inhibits adenylate cyclase and blocks cAMP production.
They are ___________________.
Beta 2
Alpha 2
Directly antagonistic
The parent molecule of adrenaline is?
Phenylalanine
Activation via beta receptors results in:
Increase glycogenolysis, gluconeogenesis, decrease glycogen deposition (skeletal muscle)
Increase fat mobilisation, lipolysis and ketogenesis
Decrease fatty acid synthesis
Increase rate and force of contraction of heart
Increase insulin secretion (low concs)
Relaxation of smooth muscles and vasodilation (low concs)
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Phenylalanine tyrosine DOPA dopamine noradrenaline adrenaline
Catecholamine synthesis
Activation via alpha1 receptors results in:
Increased urea production
Constriction of peripheral blood vessels, gut sphincters and other smooth muscles (high concentrations)
At high concentrations of alpha 2 activation…..
Insulin secretion decreases
Adrenaline is synthesised in….
Chromaffin cells of adrenal medulla