Physiology part 3 Flashcards
The incretin concept
When send glucus via jejenum –> higher insulin level than if injecting glucos via blood
Incretin
Metabolic hormones stimulates that decrese glucose levels
- e.g. GLP-1
What is digested fastes, liquid or solid meals?
Liquid
What is gasteroparesis
Slow gastric emptying
more than 60% of the meal still remains after 2 hours
How can you use the smartPill?
measures pH, transit time, temperature and pressure
in gastrointestinal tract
What is the role of ghrelin?
affect hunger contractions
What does GLP-1 do?
Inhibit gastric empty, slow down GI tract and promote insulin response
How can GLP-1 be effective to treat obesity?
Reduce gastric emptying - satiety last longer - consume less food
What is semaglutide?
An analog to GLP-1
94% homology
can help reduce weight in T2D
What happens with ghrelin levels after weight loss?
They increase after weight loss
What does gherlin regulate?
Hunger contractions
How does GLP-1 and Ghrelin affect gastric emptying?
GLP-1 - slows down
Ghrelin - speeds up
What is gastroparesis?
also called delayed gastric emptying, is a medical disorder consisting of weak muscular contractions (peristalsis) of the stomach, resulting in food and liquid remaining in the stomach for a prolonged period of time. Stomach contents thus exit more slowly into the duodenum of the digestive tract.
Which two consitions can gastroparesis lead to?
Postprandial hypoglycemia (DM1)
- rapid insulin effect by injection
Postprandial hyperglycemia (tailing) (DM2)
- Slow and low insulin incremental release
- Slow gastric emptying
What is TZP-101 ?
Ghrelin analog (recepro agonist)
