PHYSIO3-RECEPTORS Flashcards
Cholonergic receptors
Nicotinic and muscuranic
Nicotinic Receptors 1
Causes
Stimulated by
Blocked by
N1: in ganglia
Causes:rapid depolarization of post ganglionic neurons
Stimulated by: TETRAMETHYLAMMONIUM
Blocked by: BUPROPION
Nicotinic Receptor 2
Causes
Stimulated by
Blocked by
N2
Specific for skm (nmj)
Stimulated by: DECAMETHONIUM
Blocked by: TUBOCURARINE
NICOTINIC RECEPTOR MOA
Act as ion channels that open upon binding nicotine and cause influx of mostly Na and a bit of Ca.
Muscarinic receptor
G protein coupled receptor
Activate PKC
INHIBIT AC
Depo?
a1 post synaptic
Smooth muscle in bv
a2 (pre synaptic)
Autoreg, inhibition of NA and ach release
B1
Stimulating heart
B2
Relaxant effect of smooth muscle
B3
Fatty acid lipolysis