Physio Flashcards
Powerhouse of the cell
Mitochondria
Contains DNA, histones & chromosomes
Has nucleolus
NUCLEUS
Involve in detoxification,lipid synthesis, lipid-soluble substances β> water-soluble substances
SER or Agranular
For synthesis of proteins bound for the cell membrane, lysosomes, outside of the cell
RER
For synthesis of proteins bound for the cytoplasm and mitochondria
Free-floating ribosomes
For packaging, molecular tagging and synthesis of hyaluronic acid & chondroitin sulfate
Golgi Apparatus
Replenishes the cell membrane
May contain proenzymes, NTs
Secretory vesicles
For regression of tissues and AUTOLYSIS
suicide bags of the cells
Destroys FBs
Lysosomes
Degrades membrane-associated proteins
Not membrane bound
Proteosome
Contains oxidases, catalases
For detoxification
Peroxisome
SER & RER is abundant
Liver
Specialized SER in the skeletal muscles
Sarcoplasmic reticulum
Specialized RER in the neuron
Nissl substance
Only substance modified in the RER, not in Golgi
Collagen
Found in lysosome-bound proteins
Mannose 6-phosphate
Lipofuscin accumulates in this organelle
Lysosomes
Lysosomes &
Peroxisome origins
Golgi apparatus
SER
Motor protein causing transport from the cell body to the neural fibril
Kinesin
βWhip-likeβ movement on the cell surface found in the respiratory airways and Fallopian tubes
Ciliary movement
What is the common component of the protoplasm
Water
What is the common component of the cell membrane
Protein
The cell membrane is permeable to NON-POLAR molecules
True
Disk-shaped
For firm intercellular adhesion (eg epithelium)
Macula adherens
For communication (eg cardiac and smooth muscle cells) Unitary smooth muscle
Gap junctions
Ring-shaped
Increases surface area contact
Zonula adherens
Reticular
Either βtightβ (BBB, CD, terminal colon) or βleakyβ (PCT, jejunum); divides cell into apical and basolateral borders
Zonula occludens
Functional unit of a gap junction
Connexon
Movement of substances in both apical side and basolateral side
Transcellular transport
Movement of substances through tight junctions
Paracellular transport
Clathrin
SNARE proteins
Endocytosis
Exocytosis
Whatβs the most common compound on your body?
Water
Whatβs the most common protein in your body?
Collagen
Whatβs the most common amino acid in your body?
Glycine
Which of the following has a reflection coefficient closer to one?
Albumin
Passive, downhill, non-carrier-mediated
Gases, alcohol, steroid hormones
Simple diffusion
Passive, downhill, carrier-mediated
Glut-1,2,3,4,5
Facilitated diffusion
Active, uphill, carrier-mediated, uses ATP
Na-K-ATPase pump, proton pump
Primary active transport
Active, uphill, carrier-mediated, uses Na gradient
SGLT-1, SGLT-2, Na-K-2Cl
Secondary active transport
Example of IMPERMEANT solute
Glucose
Example of PERMEANT solute
UREA
Effective osmole used in the treatment of brain edema
Mannitol
Osmotic pressure from large molecules (protein)
Oncotic pressure
Weight of the volume of a solution divided by weight of equal volume of distilled (pure) water
Specific gravity
Stereospecificity, Saturation and Competition are hallmarks of carrier- or non-carrier mediated transport?
Carrier-Mediated Transport
Ca-ATPase pump in the cell membrane: PMCA Ca-ATPase in the SR & ER: SERCA. TRUE OR FALSE?
True
Osmoles per Liter of Water: osmolaRITY or osmolaLITY?
osmolaRITY
Normal osmolarity of both ECF & ICF (including CSF)?
300 mOsm/L
A RBC has an osmolarity of 300 mOsm/L. What will happen to the RBC if itβs places in a solution of:
- 300 mOsm/L Sucrose
- 300 mOsm/L Urea
No change swell
Activates G-proteins: Guanine Nucleotide Exchange (GEFs), GTPase-accelerating proteins (GAPS), regulation of protein signaling (RGS protein)
GEFs
EEG wave: relaxed
Alpha wave
EEG wave: alert ; REM sleep
Beta wave
EEG wave: deep sleep
Delta wave
Substance suspected to induce sleep
Muramyl peptide
Percentage of REM sleep in newborns
50%
Master clock
Suprachiasmatic nucleus (SCN)
Regulates master clock
Pineal gland
Detects movement of objects name low-frequency vibration; found in glabrous skin
Meissnerβs corpuscle
For continuous touch; grouped into Iggo Dome Receptors
Merkelβs disks
Detects movement of objects in skin
Hair-end organ
For pressure; for heavy and prolonged touch; found in deep skin, internal tissues and joint capsules
Ruffiniβs end organ
For high-frequency vibration; onion-like in structure
Pacinian corpuscle
Retinal glial cells that maintain internal geometry
Mueller cells
Retinal output cells whose axons from the optic nerve
Ganglion cells
Interneurons that connect rods & cones;
Contrast detectors
Bipolar cells
Absorbs stray light and prevent them from scattering
Site of macular degeneration & retinal detachment
Pigment epithelium
The first and most powerful structure of the optical system
Cornea
Center of our central vision
Fovea
Enable the lens to change its shape
Zonula
Middle vascular layer of the eye
Uvea
Film of the eye
Retina
Area of the eyes with no sensory cells
Optic disk
First part of brain to receive visual input
Optic chiasm
Relay station of the virtual cortex
Lateral geniculate body
Keep images focused in the retina
Lens
Layer of blood vessel that supplies blood to the retina
Choroid
Where aqueous humor is produced
Ciliary body
In glaucoma, these structures are blocked
Canal of SCHLEMM
Voluntary
Most number of SR
No surface calcium channels
Skeletal muscle
Contains gap junctions
Contains surface Ca-ATPase and Na-Ca exchanger
Cardiac muscle
Uses MLCK, Calmodulim, Caldesmon
Contains surface Ca-ATPase and Na-Ca exchanger
No Sarcomeres, striations, troponin
Myosin-based regulation
Contains dense bodies, caveoli, rudimentary SR
Smooth muscle
Peak or tall T waves
Hyperkalemia
Prolonged QT interval
Hypocalcemia
Prolonged PR interval
Heart blocks
ST segment elevation
Q wave MI or STEMI
An increase venous return will increase the HEART RATE
Bainbridge reflex
An increase in venous return will increase the STROKE VOLUME
Frank-Starling mechanism
AV block that cause fainting in patients due to the initially suppressed state of the Purkinje fibers
Strokes-Adams Syndrome
Powerful systemic vasoconstriction that starts at a BP<60 and optimal at BP=15
CNS Ischemic Response
Hypertension
Irregular respiration and bradycardia due to activation of the CNS ischemic response and baroreceptor reflex
Cushion reaction/reflex
Atrial contraction (distal 3rd of diastole)
Contraction of ventricles (isovolumic contraction)
Venous blood going to the atrium (isovolumic relaxation)
A wave, C wave, V wave
Caused by attempted backflow of blood during isovolumic relaxation
Incisura/Dicrotic notch
Increased ventricular pressure but same ventricular volume
Isovolumic contraction
Decreases ventricular pressure but same ventricular volume
Isovolumic relaxation
Closure of AV valves
S1
Closure of semilunar valves
S2
Rapid ventricular filling (flow of blood from atrium to ventricles)
S3
Atrial contraction/atrial systole
S4
Control conduits
May rapidly dilate and constrict
A1-vasoconstricts
B2-vasodilates
Arterioles
Stressed volume
Highest pressure
Arteries
Large cross-sectional area
Endothelial cells only
Capillaries
Capacitance vessels, 64% of blood found here! with one-way valves
Veins
Drains proteins and fluids from the interstitium, carries chylomicrons and involved in immunity and cancer
Lymphatic vessels
Forced exerted by blood against the blood vessel wall
Blood pressure
Amount of blood pumped by the heart per unit of time
Cardiac output
Amount of blood pumped per heart beat
Systolic volume
Pressure at the level of arteries and arterioles that opposes blood coming out of the heart
TPR/SVR
Total peripheral resistance/systemic vascular resistance
Number of heartbeats per minute
Heart rate
Amount of blood in the ventricle immediately before systole
End diastolic volume
Amount of blood in the ventricle immediately before diastole
End systolic volume
Ventricular contraction
Systole
Ventricular relaxation
Diastole
Low volume end diastolic volume
Preload
Aortic pressure
Afterload
Systole-Diastole
Pulse pressure
Right atrial pressure = 0mmHg
CVP
Central venous pressure
2/3 diastole + 1/3 systole
MAP
Mean arterial pressure