Phys - Autonomics Flashcards
Curare
Antagonist for Nm receptors (N1)
Atropine
Antagonist for M receptors
Hexamethonium
Antagonist for Ng receptors (N2)
Phentolamine
Antagonist for alpha receptors
Propranolol
Antagonist for beta receptors
Actions of M1 receptors
Some glands
Actions of M2 receptors
Heart
Smooth muscle
Actions of M3 receptors
Smooth muscle
Secretory glands
Actions of alpha 1 receptors
Excitatory
Vasoconstriction Ejaculation Mydriasis Thick saliva Sphincter contraction
Actions of alpha 2 receptors
Inhibitory
Decreased GI motility
Decreased GI secretions
Actions of beta 1 receptors
- HR increase (chonotropic)
- Increased strength of heart contractions (inotropic)
- renin release (increase BP)
Actions of beta 2 receptors
Relaxation of:
- GI
- Bronchiolar
- urinary bladder
- skeletal vessels
Actions of beta 3 receptors
Lipolysis
Which receptors are G coupled? What kind of coupling does each have?
qisss qiqiq
A1 A2 B1 B2 B3
M1-5
Which receptors are cholinergic receptors? Where are they located? What neurotransmitter do they go with?
ACh
Nicotinic
- Ng: cell bodies of ALL postganglionic neurons (Sympathetic and Parasympathetic)
- Nm: motor end plates of skeletal muscle
Muscarinic (M1-5)
-effector organs in the Parasympathetic system
Which receptors are adrenergic receptors? Where are they located? What neurotransmitter do they go with?
NE
Alpha and Beta
-effector organs and postganglionic axon terminals in the Sympathetic system
Eccrine sweat glands use what neurotransmitter at the effector site? Which system are they part of?
ACh
Sympathetic
NANC receptors
Non-adrenergic Non-cholinergic
Vasoactive intestinal peptide
Nitric Oxide
Substance P
Neuropeptide Y
Craniosacral Nerves go with which system?
Which CN are important here?
Parasympathetic
III, VII, IX, X
What main nerves are important for the Sympathetic system?
T1-L2
Thoracolumbar
Anabolic
Conserves energy
Vs
Catabolic
Uses energy
Parasympathetic vs Sympathetic
Actions of the Parasympathetic system
DEM BBLUESS
Defecation Emesis (vomiting) Mitosis Bradycardia Bronchoconstriction Lacrimation Urination Erection Salivation Secretion
Organophosphate poisoning
Organophosphate is an AChE inhibitor
Results:
Too much ACh
Uncontrolled skeletal muscle contractions
Mimics parasympathetic activation (DEM BBLUESS)
Radial muscles of the eye:
Receptor
Response
System
Alpha 1
Contraction, Mydriasis, dilation
Sympathetic
Sphincter muscle of iris:
Receptor
Response
System
M
Contraction, miosis
Parasympathetic
Ciliary muscles of the eye:
Receptor
Response
System
M
Contraction for near vision
Parasympathetic
Beta 2
Relaxation for far vision
Sympathetic
Normal Pressure Hydrocephalus
Classic triad
Wet, wacky, wobbly
Urinary incontinence
Dementia
Gait disturbances
Erection vs ejaculation
Systems
Point and shoot
Parasympathetic and Sympathetic
Symptoms of Botulism
Toxin
Dozen Ds: Dry mouth Diplopia (double vision) Dilated pupils Droopy eyes Diminished gag reflex Dysphagia (difficulty swallowing) Dysarthria (slurred speech) Dysphonia (difficulty speaking) Difficulty lifting head Descending paralysis Dyspnea (difficulty breathing)
