Phys Flashcards by Daniel Coquyt

What is the nemonic for CARDIAC TISSUE CONDUCTION VELOCITY?

Park At VENTure AVenue (Purkinje->Atrial Muscle->Ventricular Muscle->AV node

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WHEELHOUSE: which cytokine is produced EXLUSIVELY by lymphocytes??

IL-2

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IL-1 is primarily produced by mononuclear ________

macrophages (so i shouldn’t look for it in HGF’s??lol)

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TNF-a is a cytokine primarily produced by activated _______

macrophages

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_______ is a cytokine chiefly generated by monocytes, macrophages, B cells, and NK cells and has numberous ANTIVIRAL functions

Interferon-alpha (IFN-a)

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OOOO you should look for this primer with your HGF’s!! ____ is a cytokine secreted by macrophages, T-cells, NK cells, mast cells, endothelial cells, and FIBROBLASTS and stimularws production of granulocytes and monocytes…

GM-CSF (granulocyte-macrophage colony-stimulating factor)

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Desmosomes rely on ________ vs hemidesmosomes rely on _______ for connections

desmosomes = cadherins…hemidesmosomes = integrins

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Bullous phemphigoid is associated with ________ whereas Pemphagus vulgaris is associated with ______

goid=hemidesmosomes…gus=desmosomes

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Phospholipase C (PLC) activation is a step in the _______ second messenger system

inositol triphosphate (IP3)

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What is the immediate step in tyrosine kinase signaling activity?

DIMERIZATION after the ligand binds to the receptor

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Disorders of Sexual Development: X-linked mutation of androgen receptor, breast development, absent uterus/upper vagina/cryptorchid testes, absent pubic heair, karyotype 46, XY

COMPLETE ANDROGEN INSENSITIVITY SYNDROME (testosterone receptors thoughout the body are nonfxn)

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Disorders of Sexual Development: Hypoplastic or absent mullarian ductal system, breast development, absent or rudementary uterus/upper vagina/normal overies, normal pubic hair, karyotype 46, XX

Mullarian Agenesis

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Disorders of Sexual Development: Malformation of urogenital sinus and Mullarian ducts, breast development, normal uterus, abnormal vagina, normal overies, normal pubic hair, karyotype 46, XX

Transverse Vaginal Septum

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Disorders of Sexual Development: Complete/partial absense of 1 X chromosome, variable breast dev, normal uterus/vagina/streak overies, normal pubic hair, karyotype 45,X

Turner Syndrome

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Which type of pneumocyte makes up 97% of alveolar surfaces?

Type I pneumocyte

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Which type of pneumocyte secretes pulmonary surfactant?

Type II pneumocyte

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What is the difference between Adult Hemogobin and Fetal Hemoglobin

Adult = 2 alpha and 2 beta chains…Fetal = 2 alpha 2 gamma

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Hemoglobin Barts is incompatable with life because the fetus is missing what components?

The fetus is missing BOTH alpha chain genes and therefore cannot release oxygen

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Which cells are responsible for making ABP (androgen-binding protein)? What hormone stimulates them?

Sertoli Cells…FSH

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What cells secrete testosterone?

Leydig cells

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Glucagon binds to G protein-coupled receptors on hepatocytes, avictating ___, which in turn stimulates _______ to increase intracellular _______ levels

Gs…adenylate cyclase…cyclic AMP (cAMP)

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cAMP activates _______ which leads to the activation of key enzymes in glycogenolysis, and gluconeogenesis

protein kinase A

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Huh, interesting…what nerve would you electrocoagulate to stop excessive axillary sweating?

thoracic SYMPATHETIC trunk at the T2 segment

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Michaelis-Menten kinetics: an INCREASE in the amount of ENZYME available in a system will cause an INCREASE in _____, but NO CHANGE in ___

increase in Vmax, no change in Km

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Lineweaver-Burke: A reversible competitiive inhibitor- ____ of the enzyme INCREASES, while ____ remains UNCHANGED

Km...Vmax

Lineweaver-Burke: non competitive inhibitor- ____ DECREASES, ____ remains the same

Vmax...Km

Lineweaver-Burke: UNcompetitive inhibitor (can only bin to enzyme-substrate complex), ___ and ____ DECREASE, with NO CHANGE in the slope and therefore a Parallel line with a higher Y intercept

Km and Vmax

Which pathway does PROTHROMBIN TIME measure?

EXTRINSIC pathway (VII)

_____ kinases promote the synthesis and phosphorylation of transcription factors that control the entry of cells into the cell division cycle.

MAP kinase (mitogen-activated protein)

____ is a common SECOND MESSENGER in a G protein-coupled receptor signal transduction pathway. The FIRST effector molecule is PHOSPHOLIPASE C-gamma

DAG (diacylglycerol)

Complete me: PhosphoLipase C--->DAG and _____--->Calcium and Protein Kinase C

IP3

A DECREASED femoral-to-brachial BP ratio is associated with CO-ARC-TATION of the _______

AORTA

A HOLO-SYSTOLIC MURMUR over the LEFT STERNAL BORDER is characteristic of _________???

VENTRICULAR SEPTAL DEFECT (VSD)

In a VENTRICULAR SEPTAL DEFECT (VSD)...RIGHT atrial blood oxygenation will NOT be _________

increased

EIS-EN-MEN-GER syndrome is associated with a longstanding LEFT to RIGHT ______ and pulmonary HTN, MUCOSAL ______ and FINGER ______ can be seen

shunt...cyanosis....clubbing

Patent Ductus Arteriosis (PDA) is associated with a ________-like _______ over the UPPER percordium

MACHINE-like MURMER

A PDA (patent ductus arteriosis) allows for oxygenated blood to flow from the _______ to the _______, causing a SPIKE in the PO2 reading of this second structure.

AORTA---->PULMONARY ARTERY

HYPOCHROMIC, MICROCYTIC anemia is MOST COMMONLY caused by _______ secondary to blood loss (menstruation)

IRON deficiency

OMG WHEELHOUSE: PAGO-PHAGIA (a craving for ___) is SPECIFIC FOR _______

ICE...IRON deficiency

Pernicious anemia is a ________ anemia

MEGALOBLASTIC

OMG WHEELHOUSE: Glossal Pain, Dry mouth, atrophy of the tongue papillae

iron deficiency

The "nutcracker effect" lol: the pressure within the ____ renal vein is HIGHER due to compression between the aorta and the ______ artery.

LEFT....superior mesenteric artery

What is the main difference between a hydrocele and a varicocele? (besides location/structures involved)

Varicocele: NO transillumination...Hydrocele: Transillumination

______ is characterized by pigmented thickened plaques that arise in flexural regions such as the axillae or back of neck

Acanthosis NigRICans

Acanthosis NigRICans is usually associated with benign conditions such as INSULIN resistance or obesity...HOWEVER sudden appearance or rapid spread can signal the presence of MALIGNANCY within the _____ or _____

GI Tract or Lungs

Vitamin K is essential for the _____-________ of coagulaiton factors ___,____,___, & ____

gamma-carboxylation....II,VII,IX,X

Which antibody is INCREASED when there is a CD40L ligand decificency?

IgM

UV radiation causes _______ in DNA

THYMINE DIMERS

What does METHYLATING C-G dinucleotide repeats in the promotor region of genes do to transcription of those genes?

it SILENCES transcription of those genes

What is the MOST COMMON lysosomal storage disorder?

GAUCHER disease

ALPHA-1 receptors and EPI: it functions via the __________________ second messenger system

PHOSPHA-TI-DY-LIN-OS-ITOL

Alpha-1 receptors and EPI: when EPI binds to the alpha-1 receptor a G_ protein becomes stimulated and activates _________

Gq...PHOSPHO-LIPASE-C

Alpha-1 receptors and EPI: Phospholipase C releases ____ AND ____ from MEMBRANE PHOSPHOLIPIDS

IP3 and DAG

Alpha-1 receptors and EPI: IP3 liberates ________, while DAG activates ________...all of this ultimately leads to SMOOTH MUSCLE contraction

calcium....PROTEIN KINASE C

The SECOND heart sound (S2) results from closure of WHAT 2 VALVES?

Aortic and Pulmonic Valves

WIDE SPLITTING of heart sound 2 (S2) can occur with conditions that PROLONG _______, like a RIGHT bundle branch block or pulmonary stenosis

RIGHT VENTRICULAR EJECTION

IN GENERAL...do hydrophillic or hydrophobic materials cross the PLACENTA?

Hydrophobic readily cross the placenta...hydrophillic do not.

Which anatomical landmark of a small intestine enterocyte is responsible for producing epithelial stem cells and regeneration of the mucosal epithelium post infection?

CRYPTS of LIE_BERK_UHN

What cell type is most prominent in the progression of LIVER CIRRHOSIS?

HEPATOCYTES

What type of cell is a Kupffer cell?

a MACROPHAGE!

WHICH ION's equilibrium potential contributes THE MOST to the neuronal membrane potential during DEPOLARIZATION?

SODIUM!!

LACTOSE INTOLERANCE results from a NORMAL _________ of lactase production by small intestine enterocytes

DOWNREGULATION...(lessens genetic expression)

COPD spirometry shows increased _______ volume and total lung capasity (that shit is stretched out yo!)

Residual Volume

A fall in renal perfusion pressure (e.g. systemic hypotension, renal artery stenosis/obstruction) will cause _______ arteriole constriction. This will increase GFR, but decrease ______. THIS OVERALL CAUSES AN INCREASE in the ______ ______.

efferent...RPF (renal plasma flow)...FILTRATION FRACTION

A major cause for postural hypotension is insufficient stimulation of vascular _______1-adrenergic receptors upon standing

ALPHA1-adrenergic

Skeletal muscle (UNLIKE THE LIVER) lacks __________ and cannot produce glucose from glycogen

G-6-P (glucose-6-phosphatase)

In _________, increased intrathorasic pressure during a coughing episode decreases venous return and thus decreases cardiac output and cerebral profusion

cough syncope

When a female is pregnant and is doing a latex b-hCG urine test, agglutination in the sample = _______ and no agglutination = _______

agglutination = not pregnant.... no agglutination = pregnant

What is the most common enzyme defect of the UREA CYCLE?

OTC: Orn-i-thine Trans-Carb-amo-ylase deficiency

Defects in the OTC enzyme of the urea cycle result in accumulation of CARBAMOYL phosphate, which is converted to _______ acid by the pyrimidine biosynthetic pathway

OROTIC acid

In COLLAGEN, which AA occupies EVERY THIRD AA position, allowing compact coiling of the helix?

GLYCINE

In collagen synthesis: defective _______ hydroxylation will lead to failure of the triple helix formation and stabilization by pro-alpha chains.

PROLINE

Angiotensin 2 raises blood pressure by causing ________ in the blood vessles and promoting the secretion of _______

vasoconstriction...aldosterone

________ oxidase catalyzes the first step of the oxidative burst pathway that macrophages use to kill bacteria. A deficiency in this increases the risk of infection from CATALASE POSITIVE organisms (staph aureus)

NADPH oxidase

_______ every 7th AA (aka a "zipper") is a result of a transcription factor

Leucine